Insulin regulates brain function, but how does it get there?
Insulin regulates brain function, but how does it get there?
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DOI：
10.2337/db14-0340
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发表时间：
2014-12
期刊：
影响因子：
7.7
通讯作者：
Barrett EJ
中科院分区：
文献类型：
--
作者：
Gray SM;Meijer RI;Barrett EJ
在过去的几十年里，我们了解到大脑是胰岛素作用的重要目标。中枢神经系统 (CNS) 中的胰岛素影响进食行为和身体能量储存、肝脏和脂肪中葡萄糖和脂肪的代谢，以及记忆和认知的各个方面。胰岛素甚至可能影响阿尔茨海默病的发生或进展。然而，许多看似简单的问题（例如，胰岛素向大脑输送的途径是什么？胰岛素向大脑的输送是由胰岛素受体介导的吗？这是一个受调节的过程吗？大脑胰岛素输送是否受到胰岛素抵抗的影响？）尚未得到解答。在这里，我们简要回顾了积累的研究结果，证实了胰岛素作为中枢神经系统调节肽的重要性，检查了目前对外周胰岛素如何输送到大脑的理解，并确定了目前对该过程的理解中的关键差距。
We have learned over the last several decades that the brain is an important target for insulin action. Insulin in the central nervous system (CNS) affects feeding behavior and body energy stores, the metabolism of glucose and fats in the liver and adipose, and various aspects of memory and cognition. Insulin may even influence the development or progression of Alzheimer disease. Yet, a number of seemingly simple questions (e.g., What is the pathway for delivery of insulin to the brain? Is insulin’s delivery to the brain mediated by the insulin receptor and is it a regulated process? Is brain insulin delivery affected by insulin resistance?) are unanswered. Here we briefly review accumulated findings affirming the importance of insulin as a CNS regulatory peptide, examine the current understanding of how peripheral insulin is delivered to the brain, and identify key gaps in the current understanding of this process.
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通讯作者：
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