Postprandial administration of intranasal insulin intensifies satiety and reduces intake of palatable snacks in women.
Postprandial administration of intranasal insulin intensifies satiety and reduces intake of palatable snacks in women.
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作者：
Hallschmid M;Higgs S;Thienel M;Ott V;Lehnert H
大脑胰岛素信号在控制人类食物摄入量中的作用尚未得到彻底定义。我们假设，激素有助于食欲可口的食物，餐后调节，并评估对食欲和零食摄入的影响，餐后与空腹鼻内胰岛素给药的健康女性的大脑。两组受试者在午餐后鼻内给予160 IU胰岛素或溶剂。两小时后，在品尝测试的借口下测量不同适口性的饼干的消耗。在一项对照研究中，评估了空腹女性受试者鼻内胰岛素给药的效应。与安慰剂相比，餐后但非空腹状态下胰岛素给药降低了食欲以及巧克力饼干（提供的最可口的零食）的摄入量和评级适口性。在这两项实验中，鼻内胰岛素诱导血浆葡萄糖略有下降，但不影响血清胰岛素浓度。数据表明，脑胰岛素在餐后期间充当相关的饱腹感信号，特别是减少高可口食物的摄入，并影响外周葡萄糖稳态。餐后鼻内胰岛素给药可能有助于减少零食的过度消费，具有突出的奖励价值。
The role of brain insulin signaling in the control of food intake in humans has not been thoroughly defined. We hypothesized that the hormone contributes to the postprandial regulation of appetite for palatable food, and assessed the effects on appetite and snack intake of postprandial versus fasted intranasal insulin administration to the brain in healthy women. Two groups of subjects were intranasally administered 160 IU insulin or vehicle after lunch. Two hours later, consumption of cookies of varying palatability was measured under the pretext of a taste test. In a control study, the effects of intranasal insulin administered to fasted female subjects were assessed. Compared with placebo, insulin administration in the postprandial but not in the fasted state decreased appetite as well as intake and rated palatability of chocolate chip cookies (the most palatable snack offered). In both experiments, intranasal insulin induced a slight decrease in plasma glucose but did not affect serum insulin concentrations. Data indicate that brain insulin acts as a relevant satiety signal during the postprandial period, in particular reducing the intake of highly palatable food, and impacts peripheral glucose homeostasis. Postprandial intranasal insulin administration might be useful in curtailing overconsumption of snacks with accentuated rewarding value.
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