Body weight homeostat that regulates fat mass independently of leptin in rats and mice.
Body weight homeostat that regulates fat mass independently of leptin in rats and mice.
复制标题
体重体重稳态，可独立于大鼠和小鼠的瘦素来调节脂肪质量。
DOI：
10.1073/pnas.1715687114
复制
发表时间：
2018-01-09
影响因子：
11.1
通讯作者：
Ohlsson C
中科院分区：
文献类型：
--
作者：
Jansson JO;Palsdottir V;Hägg DA;Schéle E;Dickson SL;Anesten F;Bake T;Montelius M;Bellman J;Johansson ME;Cone RD;Drucker DJ;Wu J;Aleksic B;Törnqvist AE;Sjögren K;Gustafsson JÅ;Windahl SH;Ohlsson C
唯一已知的调节脂肪量的体内平衡的是瘦素系统。我们假设存在另一种调节体重并影响脂肪量的体内平衡器。在本研究中，我们对实验动物增加和减少体重负荷，并测量对生物体重的影响。结果表明，存在一种独立于瘦素调节脂肪量的体重稳态器。由于增加负荷的体重减轻效果依赖于骨细胞，我们建议在下肢长骨中存在一个体重传感器，作为“体重秤”。这是体重平衡器的一部分，“重力平衡器”可以保持体重和体脂质量恒定。长时间坐着的受试者肥胖风险增加，但站立抗肥胖作用的机制尚不清楚。我们假设有一种体内平衡的体重调节。我们证明，通过在腹部或背部植入不同重量的胶囊来增加啮齿动物的负荷，通过减少食物摄入来可逆地降低生物体重。重要的是，负荷减轻了饮食引起的肥胖，提高了葡萄糖耐量。已确定的体重稳态器独立于脂肪源性瘦素调节体脂肪质量，揭示了两个独立的脂肪质量调节负反馈系统。众所周知，骨细胞可以感知骨张力的变化。在这项研究中，在骨细胞缺失的小鼠中，增加负荷的减肥效果消失了。我们认为增加的体重激活了一个依赖于负重骨的骨细胞的传感器。这会诱发一个传入信号，从而减轻体重。这些发现证明了一种与瘦素无关的体重平衡器（重力平衡器）可以调节脂肪量。
The only known homeostatic regulator of fat mass is the leptin system. We hypothesized that there is a second homeostat regulating body weight with an impact on fat mass. In this study we have added and removed weight loads from experimental animals and measured the effects on the biological body weight. The results demonstrate that there is a body weight homeostat that regulates fat mass independently of leptin. As the body weight-reducing effect of increased loading was dependent on osteocytes, we propose that there is a sensor for body weight in the long bones of the lower extremities acting as “body scales.” This is part of a body weight homeostat, “gravitostat,” that keeps body weight and body fat mass constant. Subjects spending much time sitting have increased risk of obesity but the mechanism for the antiobesity effect of standing is unknown. We hypothesized that there is a homeostatic regulation of body weight. We demonstrate that increased loading of rodents, achieved using capsules with different weights implanted in the abdomen or s.c. on the back, reversibly decreases the biological body weight via reduced food intake. Importantly, loading relieves diet-induced obesity and improves glucose tolerance. The identified homeostat for body weight regulates body fat mass independently of fat-derived leptin, revealing two independent negative feedback systems for fat mass regulation. It is known that osteocytes can sense changes in bone strain. In this study, the body weight-reducing effect of increased loading was lost in mice depleted of osteocytes. We propose that increased body weight activates a sensor dependent on osteocytes of the weight-bearing bones. This induces an afferent signal, which reduces body weight. These findings demonstrate a leptin-independent body weight homeostat (“gravitostat”) that regulates fat mass.
登录
查看更多内容
影响因子：
64.5
作者：
Ferron M;Wei J;Yoshizawa T;Del Fattore A;DePinho RA;Teti A;Ducy P;Karsenty G
通讯作者：
Karsenty G
影响因子：
64.8
作者：
Mosialou I;Shikhel S;Liu JM;Maurizi A;Luo N;He Z;Huang Y;Zong H;Friedman RA;Barasch J;Lanzano P;Deng L;Leibel RL;Rubin M;Nickolas T;Chung W;Zeltser LM;Williams KW;Pessin JE;Kousteni S
通讯作者：
Kousteni S
影响因子：
64.5
作者：
Lee, Na Kyung;Sowa, Hideaki;Karsenty, Gerard
通讯作者：
Karsenty, Gerard
影响因子：
82.9
作者：
Scrocchi, LA;Brown, TJ;Drucker, DJ
通讯作者：
Drucker, DJ
影响因子：
64.8
作者：
Tschöp, M;Smiley, DL;Heiman, ML
通讯作者：
Heiman, ML