Tubeimoside I Protects Dopaminergic Neurons Against Inflammation-Mediated Damage in Lipopolysaccharide (LPS)-Evoked Model of Parkinson's Disease in Rats.
Tubeimoside I Protects Dopaminergic Neurons Against Inflammation-Mediated Damage in Lipopolysaccharide (LPS)-Evoked Model of Parkinson's Disease in Rats.
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在脂多糖 (LPS) 诱发的大鼠帕金森病模型中，马铃薯苷 I 保护多巴胺能神经元免受炎症介导的损伤
DOI：
10.3390/ijms19082242
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发表时间：
2018-07-31
影响因子：
5.6
通讯作者：
Liu D
中科院分区：
文献类型：
--
作者：
He D;Huang B;Fu S;Li Y;Ran X;Liu Y;Chen G;Liu J;Liu D
帕金森病（Parkinson's disease，PD）是一种常见的老年退行性疾病，以黑质多巴胺能神经元变性为特征。小胶质细胞过度活化引起的神经炎症在PD的发病机制中起着至关重要的作用。土贝母皂苷I（Tubeimoside I，TBMS 1）在外周组织中具有广泛的抗炎作用，但对神经炎症的影响尚未见报道。因此，我们探讨TBMS 1是否可以通过抑制脂多糖（LPS）诱导的PD大鼠模型中小胶质细胞的活化来保护多巴胺能神经元。此外，然后，在LPS暴露的小鼠小胶质细胞BV-2细胞中评估TBMS 1对神经炎症的作用和机制。体内实验结果表明，TBMS 1抑制了LPS诱导的PD大鼠模型中小胶质细胞的活化和多巴胺能神经元的减少。体外研究发现，TBMS 1可抑制LPS诱导的BV-2细胞炎症反应，其抑制作用是通过抑制蛋白激酶B（AKT）、核因子-κ B（NF-κB p65）、p38和细胞外调节蛋白激酶（ERK 1/2）的磷酸化而实现的。总之，这些结果首次证明TBMS 1通过抑制小胶质细胞介导的神经炎症在保护多巴胺能神经元中发挥作用。
Parkinson’s disease (PD), a frequent degenerative disease in the elderly, is characterized by dopaminergic neurodegeneration in the substantia nigra pars compacta (SNpc). Neuroinflammation caused by over-activated microglia plays a crucial role in the pathogenesis of PD. Tubeimoside I (TBMS1) has a broad anti-inflammatory effect in peripheral tissues, but the effect on neuroinflammation has not been reported. Therefore, we explored whether TBMS1 could protect dopaminergic neurons by inhibiting the activation of microglia in lipopolysaccharide (LPS)-induced PD rat model. In addition, then, the effect and mechanism of TBMS1 on neuroinflammation were assessed in LPS-exposed murine microglial BV-2 cells. The results in vivo showed that TBMS1 suppressed microglial activation and dopaminergic neurons’ reduction in LPS-injected PD rat model. In vitro study found that TBMS1 could inhibit LPS-induced inflammatory responses in BV-2 cells, and this effect was mediated by suppressing the phosphorylation of protein kinase B (AKT), nuclear factor-kappa B (NF-κB p65), p38 and extracellular regulated protein kinases (ERK1/2). Taken together, these results demonstrated for the first time that TBMS1 played a role in protecting dopaminergic neurons by inhibiting neuroinflammation mediated by microglia.
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影响因子：
5.6
作者：
Huang B;Liu J;Ju C;Yang D;Chen G;Xu S;Zeng Y;Yan X;Wang W;Liu D;Fu S
通讯作者：
Fu S
影响因子：
3.8
作者：
通讯作者：
--
DOI：
10.1016/j.jchromb.2006.07.053
发表时间：
2007-01-01
影响因子：
3
作者：
Liang, Ming-Jin;Zhang, Wei-Dong;Chen, Chun-Lin
通讯作者：
Chen, Chun-Lin
影响因子：
4.1
作者：
McGeer, PL;McGeer, EG
通讯作者：
McGeer, EG
DOI：
10.1007/7854_2014_356
发表时间：
2015-01-01
期刊：
BEHAVIORAL NEUROBIOLOGY OF HUNTINGTON'S DISEASE AND PARKINSON'S DISEASE
影响因子：
--
作者：
Cebrian, Carolina;Loike, John D.;Sulzer, David
通讯作者：
Sulzer, David