Motor learning drives dynamic patterns of intermittent myelination on learning-activated axons.
Motor learning drives dynamic patterns of intermittent myelination on learning-activated axons.
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DOI：
10.1038/s41593-022-01169-4
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发表时间：
2022-10
影响因子：
25
通讯作者：
Hughes, Ethan G.
中科院分区：
文献类型：
--
作者：
Bacmeister, Clara M.;Huang, Rongchen;Osso, Lindsay A.;Thornton, Michael A.;Conant, Lauren;Chavez, Anthony;Poleg-Polsky, Alon;Hughes, Ethan G.
当新形成的和预先存在的少突胶质细胞重塑现有的髓鞘形成模式时，髓鞘可塑性就发生了。髓鞘重塑是对神经元活动变化的反应，是学习和记忆所必需的。然而，行为诱导的神经元活动和髓鞘形成的回路特异性变化之间的联系仍不清楚。利用体内纵向双光子成像和小鼠学习激活神经元的靶向标记，我们探索了在学习灵活的REACH任务期间，个别皮质轴突上的间歇性髓鞘形成模式是如何改变的。我们发现，行为诱导的髓鞘可塑性针对学习激活的轴突，并发生在小鼠初级运动皮质皮质层的阶段性反应中。在学习过程中，髓鞘回缩，导致兰维尔结节延长。在运动学习之后，新形成的髓鞘的增加增加了髓鞘形成的连续伸展的数量。计算模型表明，运动学习诱导的髓鞘可塑性最初会减慢，随后会增加轴突传导速度。最后，我们表明，结节和髓鞘动力学的大小和时间都与运动学习过程中行为表现的改善有关。因此，学习诱导的和特定于神经回路的髓鞘形成变化可能有助于运动学习过程中神经回路中的信息编码。
Myelin plasticity occurs when newly-formed and pre-existing oligodendrocytes remodel existing patterns of myelination. Myelin remodeling occurs in response to changes in neuronal activity and is required for learning and memory. However, the link between behavior-induced neuronal activity and circuit-specific changes in myelination remains unclear. Using longitudinal in vivo two-photon imaging and targeted labeling of learning-activated neurons in mice, we explore how the pattern of intermittent myelination is altered on individual cortical axons during learning of a dexterous reach task. We show that behavior-induced myelin plasticity is targeted to learning-activated axons and occurs in a staged response across cortical layers in the mouse primary motor cortex. During learning, myelin sheaths retract, which results in lengthening of nodes of Ranvier. Following motor learning, addition of newly formed myelin sheaths increases the number of continuous stretches of myelination. Computational modeling suggests that motor learning-induced myelin plasticity initially slows and subsequently increases axonal conduction speed. Finally, we show that both the magnitude and timing of nodal and myelin dynamics correlate with improvement of behavioral performance during motor learning. Thus, learning-induced and circuit-specific myelination changes may contribute to information encoding in neural circuits during motor learning.
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影响因子：
64.5
作者：
Egger R;Tupikov Y;Elmaleh M;Katlowitz KA;Benezra SE;Picardo MA;Moll F;Kornfeld J;Jin DZ;Long MA
通讯作者：
Long MA
影响因子：
25
作者：
Baraban M;Koudelka S;Lyons DA
通讯作者：
Lyons DA
DOI：
10.1073/pnas.1013798107
发表时间：
2010-11-30
影响因子：
11.1
作者：
Coggan, Jay S.;Prescott, Steven A.;Sejnowski, Terrence J.
通讯作者：
Sejnowski, Terrence J.
影响因子：
64.8
作者：
Fuenfschilling, Ursula;Supplie, Lotti M.;Mahad, Don;Boretius, Susann;Saab, Aiman S.;Edgar, Julia;Brinkmann, Bastian G.;Kassmann, Celia M.;Tzvetanova, Iva D.;Moebius, Wiebke;Diaz, Francisca;Meijer, Dies;Suter, Ueli;Hamprecht, Bernd;Sereda, Michael W.;Moraes, Carlos T.;Frahm, Jens;Goebbels, Sandra;Nave, Klaus-Armin
通讯作者：
Nave, Klaus-Armin
神经元活动会影响体内髓鞘形成的轴突选择。
影响因子：
25
作者：
Hines, Jacob H.;Ravanelli, Andrew M.;Schwindt, Rani;Scott, Ethan K.;Appel, Bruce
通讯作者：
Appel, Bruce