Local Axonal Conduction Shapes the Spatiotemporal Properties of Neural Sequences.
Local Axonal Conduction Shapes the Spatiotemporal Properties of Neural Sequences.
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DOI：
10.1016/j.cell.2020.09.019
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发表时间：
2020-10-15
期刊：
影响因子：
64.5
通讯作者：
Long MA
中科院分区：
文献类型：
--
作者：
Egger R;Tupikov Y;Elmaleh M;Katlowitz KA;Benezra SE;Picardo MA;Moll F;Kornfeld J;Jin DZ;Long MA
在不同的行为和认知过程中已经观察到神经元的顺序激活，但其潜在的电路机制仍然知之甚少。在这里，我们研究了成年斑雀前脑HVC(专有名称)中的运动前序列，这是执行时间上精确的求爱歌曲的核心。我们使用高密度硅探测器来测量与歌曲相关的人口活动，并将这些观察结果与一系列网络模型的预测进行比较。我们的结果支持一种电路架构，在该电路架构中，顺序激活的神经元之间的不同延迟塑造了HVC运动前神经元活动的时空模式。我们评估了几个延迟源的影响，我们发现主要因素是通过HVC内轴突侧支的缓慢传导，这通常为序列中的每个链接增加1至7.5ms。因此，局部轴突‘延迟线’可以在决定神经回路的动态图谱中发挥重要作用。通过记录和模拟斑雀鸣叫复杂行为中参与运动控制的神经元的顺序活动，Egger等人确定，顺序激活的神经元之间的局部超低轴突传导产生网络延迟，这是电路内网络活动模式的基础。
Sequential activation of neurons has been observed during various behavioral and cognitive processes, but the underlying circuit mechanisms remain poorly understood. Here we investigate premotor sequences in HVC (proper name) of the adult zebra finch forebrain that are central to the performance of the temporally precise courtship song. We use high-density silicon probes to measure song-related population activity, and we compare these observations with predictions from a range of network models. Our results support a circuit architecture in which heterogeneous delays between sequentially active neurons shape the spatiotemporal patterns of HVC premotor neuron activity. We gauge the impact of several delay sources, and we find the primary contributor to be slow conduction through axonal collaterals within HVC, which typically adds between 1 and 7.5 ms for each link within the sequence. Thus, local axonal ‘delay lines’ can play an important role in determining the dynamical repertoire of neural circuits. By recording and modeling sequential activity in neurons involved in motor control during the complex behavior of singing in zebra finch, Egger et al., determine that local ultraslow axonal conduction between sequentially active neurons generates network delays that underlie the pattern of network activity within the circuit.
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影响因子：
3.5
作者：
Foster, David J.;Wilson, Matthew A.
通讯作者：
Wilson, Matthew A.
影响因子：
2.5
作者：
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通讯作者：
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影响因子：
1.5
作者：
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通讯作者：
Debrabant, Kristian
DOI：
10.1523/jneurosci.3196-08.2008
发表时间：
2008-09-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Giocomo LM;Hasselmo ME
通讯作者：
Hasselmo ME
影响因子：
34.7
作者：
Buzsaki, Gyoergy;Mizuseki, Kenji
通讯作者：
Mizuseki, Kenji