Virtual reality cognitive intervention for heart failure: CORE study protocol.
Virtual reality cognitive intervention for heart failure: CORE study protocol.
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DOI：
10.1002/trc2.12230
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Pressler SJ
中科院分区：
文献类型：
--
作者：
Jung M;Apostolova LG;Moser DK;Gradus-Pizlo I;Gao S;Rogers JL;Pressler SJ
心力衰竭（HF）是一种流行的严重慢性疾病，影响美国650万成年人。在HF患者中，报告的注意力障碍患病率范围为15%至27%。虽然注意力是人类活动（包括HF自我护理）的基础，但针对HF患者改善注意力的认知干预很少。使用自然环境恢复注意力的认知干预（CORE）研究旨在测试新开发的Nature‐VR的初步功效，这是一种基于自然恢复效果的基于虚拟现实的认知干预。Nature-VR开发以注意力恢复理论为指导。目标结局为注意力、HF自我护理和健康相关生活质量（HRQoL）。我们的探索性目的是检查注意力与几种假定/确定的HF生物标志物（例如，氧饱和度、脑源性神经营养因子、载脂蛋白E、多巴胺受体和多巴胺转运蛋白基因）之间的关联，以及Nature‐VR对其他领域（即，整体认知、记忆、视觉空间、执行功能和语言）的认知表现、心脏和神经系统事件以及死亡率的影响。这项单盲、两组随机对照的初步研究将入组74例HF受试者。Nature‐VR干预组将使用虚拟现实耳机观看三维自然图片，每天10分钟，每周5天，为期4周（共200分钟）。主动对照组Urban‐VR将使用虚拟现实头戴设备查看三维城市图片，以在干预剂量和输送模式方面匹配Nature‐VR干预，但在内容方面不匹配。在基线访谈后，将进行四次随访访谈，以评估第4、8、26和52周时Nature-VR的持续效果。这项研究的重要性和新奇包括使用第一种沉浸式虚拟现实技术来瞄准注意力，并在HF患者中调查Nature-VR认知干预的健康结果。
Heart failure (HF) is a prevalent, serious chronic illness that affects 6.5 million adults in the United States. Among patients with HF, the prevalence of attention impairment is reported to range from 15% to 27%. Although attention is fundamental to human activities including HF self‐care, cognitive interventions for patients with HF that target improvement in attention are scarce. The COgnitive intervention to Restore attention using nature Environment (CORE) study aims to test the preliminary efficacy of the newly developed Nature‐VR, a virtual reality‐based cognitive intervention that is based on the restorative effects of nature. Nature‐VR development was guided by Attention Restoration Theory. The target outcomes are attention, HF self‐care, and health‐related quality of life (HRQoL). Our exploratory aims examine the associations between attention and several putative/established HF biomarkers (eg, oxygen saturation, brain‐derived neurotrophic factor, apolipoprotein E, dopamine receptor, and dopamine transporter genes) as well as the effect of Nature‐VR on cognitive performance in other domains (ie, global cognition, memory, visuospatial, executive function, and language), cardiac and neurological events, and mortality. This single‐blinded, two‐group randomized‐controlled pilot study will enroll 74 participants with HF. The Nature‐VR intervention group will view three‐dimensional nature pictures using a virtual reality headset for 10 minutes per day, 5 days per week for 4 weeks (a total of 200 minutes). The active comparison group, Urban‐VR, will view three‐dimensional urban pictures using a virtual reality headset to match the Nature‐VR intervention in intervention dose and delivery mode, but not in content. After baseline interviews, four follow‐up interviews will be conducted to assess sustained effects of Nature‐VR at 4, 8, 26, and 52 weeks. The importance and novelty of this study consists of using a first‐of‐its kind, immersive virtual reality technology to target attention and in investigating the health outcomes of the Nature‐VR cognitive intervention among patients with HF.
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