MicroRNA regulation of integrins.
MicroRNA regulation of integrins.
复制标题
DOI：
10.1016/j.trsl.2013.06.008
复制
发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Jacobson JR
中科院分区：
文献类型：
--
作者：
Chen W;Harbeck MC;Zhang W;Jacobson JR
MicroRNA (miRNA) 是一类小 RNA，长度约为 20 个核苷酸，并且是非翻译的。迄今为止，已经鉴定出 700 多种 miRNA，并且它们在许多重要细胞过程中的参与现已显而易见。通过与靶标 mRNA 结合，miRNA 能够调节 mRNA 稳定性和 mRNA 翻译效率。整合素是跨膜蛋白家族，既调节细胞-基质相互作用，又作为介导细胞内信号传导和多种细胞过程（包括炎症反应、免疫反应和肿瘤发生）的受体。整合素表达也可能受到 miRNA 的调节，而 miRNA 也可以调节整合素信号传导和功能。整合素是由 α 和 β 亚基组成的异二聚体粘附蛋白。总共有 18 个 α 亚基和 8 个 β 亚基可以组合形成 24 个不同的 αβ 受体复合物。此外，每个整合素可根据其细胞外结合配体分为四组之一：胶原蛋白、层粘连蛋白、RGD (Arg-Gly-Asp) 或白细胞特异性受体。胶原配体整合素包括整合素 α1 和 α2 亚基，已知受特定 miRNA 的调节。在层粘连蛋白配体整合素中，没有已知的整合素α亚基受miRNA调节。对于RGD配体整合素，整合素α5是唯一被发现受miRNA（miR-31、miR-17-92簇和miR-148b）调节的α亚基。最后，在包含白细胞特异性受体配体整合素的 α 亚基中，整合素 αD、αL、αM、αX 已被报道受不同 miRNA 的调节。至于整联蛋白 β 亚基，迄今为止，除 β6 和 β7 外，其他所有亚基均受 miRNA 调节。然而，计算预测表明许多 miRNA 可能调节多种靶整合素。这些预测无疑将指导未来对整合素表达机制的研究，并可能最终产生新的治疗工具。
MicroRNAs (miRNAs) are a family of small RNAs which are ∼20 nucleotides in length and are non-translated. To date more than 700 miRNAs have been identified and their involvement in many essential cellular processes is now apparent. By binding with target mRNAs, miRNAs are able to regulate both mRNA stability and mRNA translational efficiency. Integrins are a family of transmembrane proteins that both regulate cell-matrix interactions and serve as receptors that mediate intracellular signaling and a variety of cellular processes, including inflammatory responses, immunoresponses, and tumorogenesis. Integrin expression may also be regulated by miRNAs which can also modulate integrin signaling and function. Integrins are heterodimer adhesion proteins comprised of an α and a β subunit. Cumulatively, there are 18 α subunits and 8 β subunits that can combine to form 24 distinct αβ receptor complexes. Additionally, each integrin can be classfied into one of four groups based on its extracellular binding ligand: collagen, laminin, RGD (Arg-Gly-Asp) or leukocyte-specific receptors. Collagen ligand integrins include integrins α1 and α2 subunits, known to be regulated by specific miRNAs. Amongst the laminin ligand integrins, there are no integrin α subunits known to be regulated by miRNA. As for the RGD ligand integrins, integrin α5 is the only α subunit found to be regulated by miRNAs (miR-31, miR-17-92 cluster, and miR-148b). Finally, amongst the α subunits that comprise the leukocyte-specific receptor ligand integrins, integrins αD, αL, αM, αX have been reported regulation by different miRNAs. As for the integrin β subunits, regulation by miRNAs has been reported for all but β6 and β7 to date. However, computational predictions suggest that numerous miRNA potentially regulate a variety of target integrins. These predictions will undoubtedly guide future investigations of mechanisms underlying integrin expression mechanism and may ultimately yield new therapeutic tools.
登录
查看更多内容
影响因子：
3.5
作者：
Hunt, Stuart;Jones, Adam V.;Lambert, Daniel W.
通讯作者：
Lambert, Daniel W.
DOI：
10.1158/1541-7786.mcr-11-0311
发表时间：
2011-11
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Augoff K;Das M;Bialkowska K;McCue B;Plow EF;Sossey-Alaoui K
通讯作者：
Sossey-Alaoui K
DOI：
10.1016/j.bbadis.2012.10.005
发表时间：
2013-07
影响因子：
6.2
作者：
Henderson, Neil C.;Sheppard, Dean
通讯作者：
Sheppard, Dean
DOI：
10.1152/ajplung.00361.2011
发表时间：
2012-08-01
影响因子：
4.9
作者：
Chen, Weiguo;Sammani, Saad;Jacobson, Jeffrey R.
通讯作者：
Jacobson, Jeffrey R.
影响因子：
11.4
作者：
HOGERVORST, F;KUIKMAN, I;SONNENBERG, A
通讯作者：
SONNENBERG, A