HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk.
HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk.
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DOI：
10.1371/journal.pone.0114212
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Sposito AC
中科院分区：
文献类型：
--
作者：
Parra ES;Panzoldo NB;Zago VH;Scherrer DZ;Alexandre F;Bakkarat J;Nunes VS;Nakandakare ER;Quintão EC;Nadruz W Jr;de Faria EC;Sposito AC
将患者错误分类为低心血管风险（LCR）仍然是一个主要问题，并对传统风险标志物的有效性提出了挑战。由于其与胆固醇受体能力的强关联，高密度脂蛋白（HDL）大小已被指定为潜在的风险标志物。因此，我们研究HDL的大小是否提高了HDL-胆固醇在确定分层为LCR的个体的颈动脉粥样硬化负荷中的预测价值。从巴西SP的Campinas和Americana市的初级保健中心，以三步程序选择了284名根据现行美国指南分类为LCR的个体（40-75岁）。载脂蛋白B的脂蛋白沉淀的聚乙二醇和HDL的大小测定动态光散射（DLS）技术。参与者被分类为HDL大小的三分位数（<7.57; 7.57-8.22; >8.22 nm）。通过高分辨率超声检查确定颈动脉内膜中层厚度（cIMT）<0.90 mm（第80百分位数），并使用多变量有序回归模型评估cIMT与HDL大小和脂质参数水平之间的相关性。HDL-胆固醇与cIMT无关。相比之下，在年龄、性别和胰岛素敏感性、种族和体重指数的稳态模型评估2指数的未校正和校正模型中，HDL大小>8.22 nm与低cIMT独立相关（比值比0.23; 95%置信区间0.07-0.74，p = 0.013）。 DLS估计的平均HDL大小构成了一个更好的预测亚临床颈动脉粥样硬化比传统的测量血浆HDL-胆固醇在个人分类为LCR。
Misclassification of patients as low cardiovascular risk (LCR) remains a major concern and challenges the efficacy of traditional risk markers. Due to its strong association with cholesterol acceptor capacity, high-density lipoprotein (HDL) size has been appointed as a potential risk marker. Hence, we investigate whether HDL size improves the predictive value of HDL-cholesterol in the identification of carotid atherosclerotic burden in individuals stratified to be at LCR. 284 individuals (40–75 years) classified as LCR by the current US guidelines were selected in a three-step procedure from primary care centers of the cities of Campinas and Americana, SP, Brazil. Apolipoprotein B-containing lipoproteins were precipitated by polyethylene glycol and HDL size was measured by dynamic light scattering (DLS) technique. Participants were classified in tertiles of HDL size (<7.57; 7.57–8.22; >8.22 nm). Carotid intima-media thickness (cIMT) <0.90 mm (80th percentile) was determined by high resolution ultrasonography and multivariate ordinal regression models were used to assess the association between cIMT across HDL size and levels of lipid parameters. HDL-cholesterol was not associated with cIMT. In contrast, HDL size >8.22 nm was independently associated with low cIMT in either unadjusted and adjusted models for age, gender and Homeostasis Model Assessment 2 index for insulin sensitivity, ethnicity and body mass index (Odds ratio 0.23; 95% confidence interval 0.07–0.74, p = 0.013). The mean HDL size estimated with DLS constitutes a better predictor for subclinical carotid atherosclerosis than the conventional measurements of plasma HDL-cholesterol in individuals classified as LCR.
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影响因子：
2.1
作者：
Kahn HS
通讯作者：
Kahn HS
影响因子：
6.5
作者：
Oka, T;Yamashita, S;Hattori, H
通讯作者：
Hattori, H
DOI：
10.1161/atvbaha.113.301373
发表时间：
2013-07
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Li XM;Tang WH;Mosior MK;Huang Y;Wu Y;Matter W;Gao V;Schmitt D;Didonato JA;Fisher EA;Smith JD;Hazen SL
通讯作者：
Hazen SL
影响因子：
2.8
作者：
Rosenson, RS;Otvos, JD;Freedman, DS
通讯作者：
Freedman, DS
影响因子：
5.8
作者：
Dullaart, Robin P. F.;Perton, Frank;van Tol, Arie
通讯作者：
van Tol, Arie