Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices.
Exploiting Generative Design for 3D Printing of Bacterial Biofilm Resistant Composite Devices.
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DOI：
10.1002/advs.202100249
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Wildman RD
中科院分区：
文献类型：
--
作者：
He Y;Abdi M;Trindade GF;Begines B;Dubern JF;Prina E;Hook AL;Choong GYH;Ledesma J;Tuck CJ;Rose FRAJ;Hague RJM;Roberts CJ;De Focatiis DSA;Ashcroft IA;Williams P;Irvine DJ;Alexander MR;Wildman RD
随着对疾病了解的加深，针对个人需求的个性化治疗的机会也在增加。为了实现医疗设备个性化的阶跃变化，事实证明，基于喷墨的多材料 3D 打印可以通过结合功能材料、体素化制造和算法设计来满足这一需求。在本文中，使用两种选择性且单独沉积的配方制造了具有受控变形和减少生物膜形成的复合结构。与常用的硅橡胶相比，所得复合材料的细菌生物膜覆盖率减少高达 75%，且无需掺入生物活性剂。同时，可以对复合材料进行调整以满足用户定义的机械性能，偏差为±10%。设备制造与有限元建模和遗传算法相结合，遗传算法采用用户指定的机械变形，并通过生成设计过程计算在给定负载约束下满足此要求所需的材料分布。根据机械和细菌细胞指导规范对制成的产品进行评估，并说明如何使用基于生成设计驱动的多材料喷墨 3D 打印来实现多功能个性化。基于多材料喷墨的 3D 打印用于个性化医疗设备的设计和制造。设计优化方法用于指定两种不同材料的位置，每种材料具有不同的模量，但都具有抵抗细菌定植的能力（比医用有机硅高出 75%），从而满足用户定义的复杂设计约束。
As the understanding of disease grows, so does the opportunity for personalization of therapies targeted to the needs of the individual. To bring about a step change in the personalization of medical devices it is shown that multi‐material inkjet‐based 3D printing can meet this demand by combining functional materials, voxelated manufacturing, and algorithmic design. In this paper composite structures designed with both controlled deformation and reduced biofilm formation are manufactured using two formulations that are deposited selectively and separately. The bacterial biofilm coverage of the resulting composites is reduced by up to 75% compared to commonly used silicone rubbers, without the need for incorporating bioactives. Meanwhile, the composites can be tuned to meet user defined mechanical performance with ±10% deviation. Device manufacture is coupled to finite element modelling and a genetic algorithm that takes the user‐specified mechanical deformation and computes the distribution of materials needed to meet this under given load constraints through a generative design process. Manufactured products are assessed against the mechanical and bacterial cell‐instructive specifications and illustrate how multifunctional personalization can be achieved using generative design driven multi‐material inkjet based 3D printing. Multi‐material inkjet‐based 3D printing is used for the design and manufacture of personalized medical devices. A design optimization approach is used to specify the location of two different materials, each with a different moduli, but both with the ability to resist bacterial colonization (up to 75% better than medical silicones), such that they meet user‐defined, complex design constraints.
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影响因子：
46.9
作者：
通讯作者：
--
DOI：
10.1056/nejmoa1306801
发表时间：
2014-03-27
期刊：
The New England journal of medicine
影响因子：
--
作者：
Magill SS;Edwards JR;Bamberg W;Beldavs ZG;Dumyati G;Kainer MA;Lynfield R;Maloney M;McAllister-Hollod L;Nadle J;Ray SM;Thompson DL;Wilson LE;Fridkin SK;Emerging Infections Program Healthcare-Associated Infections and Antimicrobial Use Prevalence Survey Team
通讯作者：
Emerging Infections Program Healthcare-Associated Infections and Antimicrobial Use Prevalence Survey Team
影响因子：
4.1
作者：
Ge, Qi;Dunn, Conner K.;Dunn, Martin L.
通讯作者：
Dunn, Martin L.
影响因子：
11
作者：
Han, Daehoon;Yang, Chen;Lee, Howon
通讯作者：
Lee, Howon
影响因子：
1.7
作者：
Keenan, Michael R.;Smentkowski, Vincent S.
通讯作者：
Smentkowski, Vincent S.