Long-term occupational exposure to organic solvents affects color vision, contrast sensitivity and visual fields.
Long-term occupational exposure to organic solvents affects color vision, contrast sensitivity and visual fields.
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DOI：
10.1371/journal.pone.0042961
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Ventura DF
中科院分区：
文献类型：
--
作者：
Costa TL;Barboni MT;Moura AL;Bonci DM;Gualtieri M;de Lima Silveira LC;Ventura DF
本研究的目的是通过测量一组加油站工人的颜色辨别力、非彩色对比敏感度和视野来评估慢性职业暴露于有机溶剂混合物的视觉结果。我们测试了25名工人（20名男性）和25名对照组，没有长期暴露于溶剂的历史（10名男性）。所有参与者的眼科检查均正常。受试者在加油站工作的平均时间为9.6±6.2年。用Lanthony D15 d和剑桥颜色测试（CCT）评价色觉。视野评估包括白对白色24-2自动视野检查（Humphrey II-750 i）。对比敏感度测量正弦光栅的0.2，0.5，1.0，2.0，5.0，10.0和20.0周每度（cpd）。使用Mann-Whitney U检验比较两组的结果。在D15 d中，工人的错误数高于对照组（p<0.01）。与对照组相比，其CCT色觉阈值在原色、Deutan色和Tritan色混淆轴上沿着升高（p<0.01），椭圆面积和椭圆率更高（p<0.01）。对具有非常高的颜色辨别阈值的受试者进行的遗传分析排除了视觉损失的先天性原因。自动视野检查阈值显示偏心9°、15°和21°（p<0.01）以及MD和PSD指数（p<0.01）升高。除0.5 cpd外，所有测量的空间频率的对比敏感度均下降（p<0.01）。发现之前的工作年限与Deutan轴阈值（rho = 0.59; p<0.05）、Lanthony D15 d指数（rho = 0.52; p<0.05）、中央凹视野检查结果（rho =-0.51; p<0.05）和偏心度3、9和15度视野检查结果（rho =-0.46; p<0.05）之间存在显著相关性。 广泛和弥漫性的视觉变化，发现，这表明应创建特定的职业限制。
The purpose of this study was to evaluate the visual outcome of chronic occupational exposure to a mixture of organic solvents by measuring color discrimination, achromatic contrast sensitivity and visual fields in a group of gas station workers. We tested 25 workers (20 males) and 25 controls with no history of chronic exposure to solvents (10 males). All participants had normal ophthalmologic exams. Subjects had worked in gas stations on an average of 9.6±6.2 years. Color vision was evaluated with the Lanthony D15d and Cambridge Colour Test (CCT). Visual field assessment consisted of white-on-white 24–2 automatic perimetry (Humphrey II-750i). Contrast sensitivity was measured for sinusoidal gratings of 0.2, 0.5, 1.0, 2.0, 5.0, 10.0 and 20.0 cycles per degree (cpd). Results from both groups were compared using the Mann–Whitney U test. The number of errors in the D15d was higher for workers relative to controls (p<0.01). Their CCT color discrimination thresholds were elevated compared to the control group along the protan, deutan and tritan confusion axes (p<0.01), and their ellipse area and ellipticity were higher (p<0.01). Genetic analysis of subjects with very elevated color discrimination thresholds excluded congenital causes for the visual losses. Automated perimetry thresholds showed elevation in the 9°, 15° and 21° of eccentricity (p<0.01) and in MD and PSD indexes (p<0.01). Contrast sensitivity losses were found for all spatial frequencies measured (p<0.01) except for 0.5 cpd. Significant correlation was found between previous working years and deutan axis thresholds (rho = 0.59; p<0.05), indexes of the Lanthony D15d (rho = 0.52; p<0.05), perimetry results in the fovea (rho = −0.51; p<0.05) and at 3, 9 and 15 degrees of eccentricity (rho = −0.46; p<0.05). Extensive and diffuse visual changes were found, suggesting that specific occupational limits should be created.
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影响因子：
9.8
作者：
Costa, Marcelo Fernandes;Oliveira, Andre Gustavo Fernandes;Ventura, Dora Fix
通讯作者：
Ventura, Dora Fix
影响因子：
7.3
作者：
Bale, AS;Smothers, CT;Woodward, JJ
通讯作者：
Woodward, JJ
影响因子：
--
作者：
Lacerda EM;Lima MG;Rodrigues AR;Teixeira CE;de Lima LJ;Ventura DF;Silveira LC
通讯作者：
Silveira LC
影响因子：
2.4
作者：
Kiyokawa, M;Mizota, A;Adachi-Usami, E
通讯作者：
Adachi-Usami, E
DOI：
10.1007/s004200050204
发表时间：
1997-09-01
影响因子：
3
作者：
Edling, C;Hellman, B;Langstrom, B
通讯作者：
Langstrom, B