Differences in Several Factors in the Development of Erosive Esophagitis Among Patients at Various Stages of Metabolic Syndrome: A Cross-Sectional Study.
Differences in Several Factors in the Development of Erosive Esophagitis Among Patients at Various Stages of Metabolic Syndrome: A Cross-Sectional Study.
复制标题
DOI：
10.2147/dmso.s298326
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Takayama T
中科院分区：
文献类型：
--
作者：
Sogabe M;Okahisa T;Kurihara T;Kagawa M;Kagemoto K;Kida Y;Tomonari T;Taniguchi T;Okamoto K;Miyamoto H;Sato Y;Nakasono M;Takayama T
糜烂性食管炎（EE）与代谢综合征（MS）密切相关，但在MS患者中并不总是被发现，而在非MS患者中，EE的患病率也不低。研究MS不同阶段与EE相关的临床因素的差异，以及MS受试者、有EE受试者和没有EE受试者之间代谢物的差异。共有7097人接受了包括食管胃十二指肠镜检查在内的健康检查。我们研究了非多发性硬化、前期多发性硬化和多发性硬化患者之间情感表达临床因素的差异，并比较了34名多发性硬化、有和没有情感表达的患者之间的代谢物。多发性硬化症和前期多发性硬化症组的EE患病率显著高于非多发性硬化症组（p < 0.001）。MS组的EE严重程度高于MS前组和非MS组（p < 0.001）。在非ms组中，有和没有EE的受试者在幽门螺杆菌（H. pylori）和吸烟方面存在显著差异。在MS前组和MS组中，有和没有EE的人在幽门螺杆菌、裂孔疝和饮酒方面存在显著差异。谷氨酰胺、次黄嘌呤和乳酸代谢物水平在多发性硬化症、伴EE和不伴EE患者之间差异有统计学意义（均p < 0.05）。虽然幽门螺杆菌和生活方式因素（如吸烟和饮酒）对情感表达很重要，但在多发性硬化症的不同阶段，这些因素的差异应被考虑在内。此外，多发性硬化症中情感表达的发展可能涉及几种代谢物。
Erosive esophagitis (EE) is strongly associated with metabolic syndrome (MS), but is not always recognized in individuals with MS and the prevalence of EE in individuals with non-MS is not low. To examine the differences in clinical factors associated with EE at various stages of MS, as well as the differences in metabolites between subjects with MS, with and without EE. A total of 7,097 persons who underwent health checkups including esophagogastroduodenoscopy were analyzed. We examined the differences in clinical factors for EE among subjects with non-MS, pre-MS, and MS and compared metabolites between 34 subjects with MS, with and without EE. EE prevalence was significantly higher in the MS and pre-MS groups than in the non-MS group (p < 0.001). EE severity was higher in the MS group than in the pre-MS and non-MS groups (p < 0.001). In the non-MS group, there were significant differences between subjects with and without EE with respect to Helicobacter pylori (H. pylori) and smoking. In the pre-MS and MS groups, there were significant differences in H. pylori, hiatal hernia, and drinking in those with and without EE. The levels of glutamine, hypoxanthine, and lactic acid metabolites were significantly different between subjects with MS, with and without EE (all p < 0.05). Although H. pylori and lifestyle factors such as smoking and drinking are important for EE, differences in these factors should be considered at various stages of MS. Additionally, several metabolites may be involved in the development of EE in MS.
影响因子：
3.7
作者：
Chih PC;Yang YC;Wu JS;Chang YF;Lu FH;Chang CJ
通讯作者：
Chang CJ