Overweight associated with increased risk of erosive esophagitis in a non-obese Taiwanese population.
Overweight associated with increased risk of erosive esophagitis in a non-obese Taiwanese population.
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DOI：
10.1371/journal.pone.0077932
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Chang CJ
中科院分区：
文献类型：
--
作者：
Chih PC;Yang YC;Wu JS;Chang YF;Lu FH;Chang CJ
探讨台湾非肥胖人群中超重与糜烂性食管炎（EE）的关系。研究对象为国立成功大学医院健康检查中心的7，352名受试者（非肥胖者5，826名;肥胖者1，526名）。中心性肥胖定义为男性腰围（WC）≥90 cm，女性≥ 80 cm。超重定义为体重指数（BMI）24-26.9 kg/m2，全身肥胖定义为BMI ≥27 kg/m2。采用洛杉矶分类法判定EE的存在。在总肥胖人群和非肥胖人群中，有EE者与无EE者的中心性肥胖患病率和不同BMI状态存在显著差异。在总人群中，多变量分析显示，中心性肥胖（OR，1.17，95%CI，1.02-1.34，p = 0.021）和肥胖（OR，1.28，95%CI，1.07-1.52，p = 0.007）/超重（OR，1.25，95%CI，1.08-1.45，p = 0.003）分别与EE呈正相关。 当考虑中心性肥胖和BMI状态的联合效应时，超重（OR，1.22; 95%CI，1.04-1.44; p = 0.016）仍然是EE的独立相关因素，但中心性肥胖（OR，1.06; 95%CI，0.89-1.26; p = 0.549）/肥胖（OR，1.22; 95%CI，0.98-1.53; p = 0.082）不是。 对于非肥胖组，独立模型显示中心性肥胖（OR，1.19，95% CI，1.00-1.40，p = 0.046）和超重（OR，1.24; 95% CI，1.07-1.44，p = 0.005）分别与EE呈正相关。 然而，超重（OR，1.20; 95%CI，1.02-1.42，p = 0.030）而不是中心性肥胖（OR，1.08; 95%CI，0.90-1.31; p = 0.398）与EE正相关，同时考虑超重和中心性肥胖的影响。 在非肥胖受试者中，超重对EE的影响比中心性肥胖更有害。此外，男性、食管裂孔疝和饮酒也与EE风险增加相关。
To investigate the relationship between overweight and erosive esophagitis (EE) in a non-obese Taiwanese population. A total of 7,352 subjects (non-obese, 5,826; obese, 1,526) from a health examination center at National Cheng Kung University Hospital were enrolled. Central obesity was defined by a waist circumference (WC) ≥90 cm in male and 80 cm in female. Overweight was defined as body mass index (BMI) of 24–26.9 kg/m2, and general obesity as BMI ≥27 kg/m2. The Los Angeles classification was adopted to determine the presence of EE. There were significant differences in the prevalence of central obesity and different BMI status between subjects with and without EE in total and non-obese population. In total population, multivariate analyses revealed central obesity (OR, 1.17, 95% CI, 1.02–1.34, p = 0.021) and being obese (OR, 1.28, 95% CI, 1.07–1.52, p = 0.007)/overweight (OR, 1.25, 95% CI, 1.08–1.45, p = 0.003) had positive associations with EE in different model, respectively. When considering the joint effect of central obesity and BMI status, overweight (OR, 1.22; 95% CI, 1.04–1.44; p = 0.016) remained as an independent associated factor of EE but central obesity (OR, 1.06; 95% CI, 0.89–1.26; p = 0.549)/being obese (OR, 1.22; 95% CI, 0.98–1.53; p = 0.082) did not. As for non-obese group, separate model showed central obesity (OR, 1.19, 95% CI, 1.00–1.40, p = 0.046) and overweight (OR, 1.24; 95% CI, 1.07–1.44, p = 0.005) was positively associated with EE, respectively. However, being overweight (OR, 1.20; 95% CI, 1.02–1.42, p = 0.030) but not central obesity (OR, 1.08; 95% CI, 0.90–1.31; p = 0.398) was positively related to EE with considering the effect of overweight and central obesity simultaneously. Overweight effect on EE was more detrimental than central obesity in non-obese subjects. In addition, male gender, hiatus hernia and alcohol use were also associated with increased risk of EE.
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影响因子：
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作者：
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