A two-segment model for thin filament architecture in skeletal muscle.

A two-segment model for thin filament architecture in skeletal muscle.
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DOI:
10.1038/nrm3510
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发表时间:
2013-02
期刊:
Nature reviews. Molecular cell biology
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其他
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正确的肌丝长度规格对于骨骼肌的有效收缩至关重要。细丝长度最好通过新颖的“两段”模型来指定,其中细丝由恒定或可变长度的两个串联段组成,而不是通过经典的“星云尺”模型来指定,其中细丝是均匀结构,其长度由星云决定。两段模型暗示肌动蛋白动力学的位置特异性“差异微调节”是肌动蛋白丝长度和稳定性的一般原理。
Correct specification of myofilament lengths is essential for efficient skeletal muscle contraction. Thin filament lengths are best specified by a novel ‘two-segment’ model, wherein the thin filament consists of two concatenated segments, of either constant or variable length, rather than by the classical ‘nebulin ruler’ model, wherein the thin filament is a uniform structure whose length is dictated by nebulin. The two-segment model implicates position-specific ‘differential microregulation’ of actin dynamics as a general principle underlying actin filament lengths and stability.
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