flan: An R Package for Inference on Mutation Models
flan: An R Package for Inference on Mutation Models
复制标题
flan：用于突变模型推理的 R 包
DOI：
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
B. Ycart
中科院分区：
文献类型：
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作者：
Adrien Mazoyer;R. Drouilhet;S. Despréaux;B. Ycart
本文介绍了 flan，这是一个提供突变细胞计数波动分析工具的软件包。它包括专用于突变细胞最终数量分布的函数。还实现了参数估计和假设检验，从而可以使用多种可能的方法对不同类型的数据进行推断。提出了该主题的概述。描述了突变模型的一般形式，包括作为特殊情况的经典模型。当数据由另一个模型生成时，根据模型进行估计会引起不同的可能偏差，这些偏差将被识别和讨论。描述了包中可用的三种估计方法，并比较了它们的均方误差。最后，讨论了实现，并给出了一些在实际数据集上使用的示例。
This paper describes flan, a package providing tools for fluctuation analysis of mutant cell counts. It includes functions dedicated to the distribution of final numbers of mutant cells. Parametric estimation and hypothesis testing are also implemented, enabling inference on different sorts of data with several possible methods. An overview of the subject is proposed. The general form of mutation models is described, including the classical models as particular cases. Estimating from a model, when the data have been generated by another, induces different possible biases, which are identified and discussed. The three estimation methods available in the package are described, and their mean squared errors are compared. Finally, implementation is discussed, and a few examples of usage on real data sets are given.
影响因子：
4.3
作者：
Dewanji, A;Luebeck, EG;Moolgavkar, SH
通讯作者：
Moolgavkar, SH