Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder.
Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder.
复制标题
DOI：
10.1001/jamapsychiatry.2013.3469
复制
发表时间：
2014-02
期刊：
影响因子：
25.8
通讯作者：
Oenguer, Dost
中科院分区：
文献类型：
--
作者：
Baker, Justin T.;Holmes, Avram J.;Masters, Grace A.;Yeo, B. T. Thomas;Krienen, Fenna;Buckner, Randy L.;Oenguer, Dost
精神障碍（包括精神分裂症、情感性精神障碍和精神病性双相情感障碍）是以信息处理整合障碍为特征的毁灭性疾病。神经影像学的最新进展允许在内在功能连接的基础上估计大脑网络，但对精神病性障碍中的特定网络异常知之甚少。比较精神分裂症谱系障碍或精神病性双相情感障碍患者和健康对照者大脑皮层的内在功能连接。我们研究了2009年12月至2011年10月期间来自学术精神病医院的100例患者（28例精神分裂症患者，32例情感障碍患者，40例双相情感障碍伴精神病患者）和100例年龄，性别，种族，利手和扫描质量匹配的健康对照。覆盖整个大脑皮层的122个区域的功能连接概况。相对于健康对照组，精神病患者的多个大脑网络受到破坏，额顶叶控制网络内的功能连接优先减少（P <0.05，校正了家庭错误率）。这个功能定义的网络包括背外侧前额叶皮层、后内侧前额叶皮层、外侧顶叶皮层和后颞叶皮层的部分。这种效应在诊断中可见，并在基于扫描质量匹配患者和对照组后持续存在。我们的研究结果支持这样的观点，即大脑皮层信息处理在精神病中被破坏，并提供了新的证据，即额顶叶控制网络内的破坏可能是精神分裂症和情感性精神病的共同特征。
Psychotic disorders (including schizophrenia, schizoaffective disorder, and psychotic bipolar disorder) are devastating illnesses characterized by breakdown in the integration of information processing. Recent advances in neuroimaging allow for the estimation of brain networks on the basis of intrinsic functional connectivity, but the specific network abnormalities in psychotic disorders are poorly understood. To compare intrinsic functional connectivity across the cerebral cortex in patients with schizophrenia spectrum disorders or psychotic bipolar disorder and healthy controls. We studied 100 patients from an academic psychiatric hospital (28 patients with schizophrenia, 32 patients with schizoaffective disorder, and 40 patients with bipolar disorder with psychosis) and 100 healthy controls matched for age, sex, race, handedness, and scan quality from December 2009 to October 2011. Functional connectivity profiles across 122 regions that covered the entire cerebral cortex. Relative to the healthy controls, individuals with a psychotic illness had disruption across several brain networks, with preferential reductions in functional connectivity within the frontoparietal control network (P < .05, corrected for family-wise error rate). This functionally defined network includes portions of the dorsolateral prefrontal cortex, posteromedial prefrontal cortex, lateral parietal cortex, and posterior temporal cortex. This effect was seen across diagnoses and persisted after matching patients and controls on the basis of scan quality. Our study results support the view that cortical information processing is disrupted in psychosis and provides new evidence that disruptions within the frontoparietal control network may be a shared feature across both schizophrenia and affective psychosis.
登录
查看更多内容
影响因子：
4.7
作者：
Calhoun VD;Sui J;Kiehl K;Turner J;Allen E;Pearlson G
通讯作者：
Pearlson G
在认知控制性能过程中，第一期精神分裂症中的一般和特定的功能连通性干扰。
影响因子：
10.6
作者：
Fornito, Alex;Yoon, Jong;Zalesky, Andrew;Bullmore, Edward T.;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
DOI：
10.1098/rstb.1996.0136
发表时间：
1996-10-29
影响因子：
6.3
作者：
Frith, C
通讯作者：
Frith, C
影响因子：
17.7
作者：
Perlstein, WM;Carter, CS;Cohen, JD
通讯作者：
Cohen, JD
影响因子：
5.7
作者：
Jafri, Madiha J.;Pearlson, Godfrey D.;Calhoun, Vince D.
通讯作者：
Calhoun, Vince D.