General and specific functional connectivity disturbances in first-episode schizophrenia during cognitive control performance.
General and specific functional connectivity disturbances in first-episode schizophrenia during cognitive control performance.
复制标题
在认知控制性能过程中，第一期精神分裂症中的一般和特定的功能连通性干扰。
DOI：
10.1016/j.biopsych.2011.02.019
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发表时间：
2011-07-01
影响因子：
10.6
通讯作者：
Carter, Cameron S.
中科院分区：
文献类型：
--
作者：
Fornito, Alex;Yoon, Jong;Zalesky, Andrew;Bullmore, Edward T.;Carter, Cameron S.
精神分裂症的认知控制障碍被认为是由大脑区域互联网络的功能障碍引起的，但是在认知任务执行过程中询问大规模大脑网络的功能动力学已经被证明是困难的。我们使用功能性磁共振成像来生成与事件相关的全脑功能连接网络，参与者与首发精神分裂症和健康对照受试者进行认知控制任务。在23名患者和25名对照受试者的每对78个大脑区域之间评估了认知控制性能期间的功能连接。网络属性检查区域明智的连接，边明智的连接，全球路径长度，集群，小世界，全球效率和本地效率。患者在大规模的大脑区域网络中表现出广泛的功能连接缺陷，这主要影响额叶皮层和后部区域之间的连接，并且无论任务背景如何都会发生。与认知控制相关的额顶叶系统中更受限制和任务特异性的连接障碍也很明显。患者的网络拓扑结构的全局属性相对完整。精神分裂症的第一次发作与影响大多数大脑区域的广泛连接障碍有关，但这在额叶皮层特别明显。叠加在这种普遍的缺陷，患者表现出更具体的认知控制相关的功能连接减少额顶叶区域。这些连通性缺陷发生在相对保存的全球网络组织的背景下。
Cognitive control impairments in schizophrenia are thought to arise from dysfunction of interconnected networks of brain regions, but interrogating the functional dynamics of large-scale brain networks during cognitive task performance has proved difficult. We used functional magnetic resonance imaging to generate event-related whole-brain functional connectivity networks in participants with first-episode schizophrenia and healthy control subjects performing a cognitive control task. Functional connectivity during cognitive control performance was assessed between each pair of 78 brain regions in 23 patients and 25 control subjects. Network properties examined were region-wise connectivity, edge-wise connectivity, global path length, clustering, small-worldness, global efficiency, and local efficiency. Patients showed widespread functional connectivity deficits in a large-scale network of brain regions, which primarily affected connectivity between frontal cortex and posterior regions and occurred irrespective of task context. A more circumscribed and task-specific connectivity impairment in frontoparietal systems related to cognitive control was also apparent. Global properties of network topology in patients were relatively intact. The first episode of schizophrenia is associated with a generalized connectivity impairment affecting most brain regions but that is particularly pronounced for frontal cortex. Superimposed on this generalized deficit, patients show more specific cognitive-control-related functional connectivity reductions in frontoparietal regions. These connectivity deficits occur in the context of relatively preserved global network organization.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
14.5
作者：
Benetti, Stefania;Mechelli, Andrea;McGuire, Philip
通讯作者：
McGuire, Philip
影响因子：
6.9
作者：
Fornito, Alex;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
影响因子：
10.6
作者：
Ford, JM;Mathalon, DH;Roth, WT
通讯作者：
Roth, WT