Harnessing Protein Corona for Biomimetic Nanomedicine Design.
Harnessing Protein Corona for Biomimetic Nanomedicine Design.
复制标题
利用蛋白电晕进行仿生纳米医学设计
DOI：
10.3390/biomimetics7030126
复制
发表时间：
2022-09-06
期刊：
影响因子：
4.5
通讯作者：
Wang, Zhe
中科院分区：
文献类型：
--
作者：
Chen, Zhidong;Chen, Xu;Huang, Juyang;Wang, Junqing;Wang, Zhe
纳米颗粒（NPs）通常被视为多功能药物，结合了几种治疗应用，如成像和靶向递送。然而，临床翻译仍然在很大程度上受到几个因素的阻碍，纳米颗粒表面快速形成的蛋白质冠就是其中之一。蛋白质冠的形成在生物环境中是复杂的、不可逆的，蛋白质冠将重新定义纳米粒的“生物学身份”，这将改变随后的生物学事件和治疗效果。目前对蛋白质冠的认识仍然有限和不完整，在许多情况下，蛋白质冠对纳米医学产生不利影响，例如失去靶向能力，激活免疫反应，快速清除。由于蛋白质冠在纳米粒子的生物命运中的重要作用，利用蛋白质冠通过各种方法如仿生方法来实现一些治疗效果，现在被视为一种有前途的方法，以满足当前纳米医学的挑战，如不良的药代动力学特性，脱靶效应和免疫原性。本文首先介绍了蛋白质冠的研究现状，并对蛋白质冠的研究过程和技术进行了综述。其次，综述了利用蛋白质冠进行纳米药物设计的仿生方法。最后，我们讨论了纳米医学中仿生方法调节蛋白质冠的挑战和未来展望。
Nanoparticles (NPs) are usually treated as multifunctional agents combining several therapeutical applications, like imaging and targeting delivery. However, clinical translation is still largely hindered by several factors, and the rapidly formed protein corona on the surface of NPs is one of them. The formation of protein corona is complicated and irreversible in the biological environment, and protein corona will redefine the “biological identity” of NPs, which will alter the following biological events and therapeutic efficacy. Current understanding of protein corona is still limited and incomplete, and in many cases, protein corona has adverse impacts on nanomedicine, for instance, losing targeting ability, activating the immune response, and rapid clearance. Due to the considerable role of protein corona in NPs’ biological fate, harnessing protein corona to achieve some therapeutic effects through various methods like biomimetic approaches is now treated as a promising way to meet the current challenges in nanomedicine such as poor pharmacokinetic properties, off-target effect, and immunogenicity. This review will first introduce the current understanding of protein corona and summarize the investigation process and technologies. Second, the strategies of harnessing protein corona with biomimetic approaches for nanomedicine design are reviewed. Finally, we discuss the challenges and future outlooks of biomimetic approaches to tune protein corona in nanomedicine.
登录
查看更多内容
影响因子：
7.4
作者：
Bose RJ;Ha K;McCarthy JR
通讯作者：
McCarthy JR
DOI：
10.1073/pnas.2109256118
发表时间：
2021-12-28
影响因子：
11.1
作者：
Dilliard, Sean A.;Cheng, Qiang;Siegwart, Daniel J.
通讯作者：
Siegwart, Daniel J.
影响因子：
17.1
作者：
Corbo, Claudia;Molinaro, Roberto;Tasciotti, Ennio
通讯作者：
Tasciotti, Ennio
影响因子：
8
作者：
Amin, Mohamadreza;Bagheri, Mahsa;ten Hagen, Timo L. M.
通讯作者：
ten Hagen, Timo L. M.
DOI：
10.1073/pnas.2200363119
发表时间：
2022-06-07
影响因子：
11.1
作者：
通讯作者：
--