Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs.
Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs.
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DOI：
10.1371/journal.pone.0050141
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Weichselbaum RR
中科院分区：
文献类型：
--
作者：
Lussier YA;Khodarev NN;Regan K;Corbin K;Li H;Ganai S;Khan SA;Gnerlich JL;Darga TE;Fan H;Karpenko O;Paty PB;Posner MC;Chmura SJ;Hellman S;Ferguson MK;Weichselbaum RR
癌症分期和治疗的策略依赖于局部或广泛转移性疾病的假设。一种以进展有限为特征的中间转移状态被称为寡转移（es）。少转移瘤可通过手术切除或放射治疗。我们分析了以治疗为目的切除≤5个初始转移灶患者肺转移样本中的microRNA表达模式。根据患者的转移进展率将其分为亚组。我们在复发率最高和最低的患者之间优先考虑microrna。我们将其命名为高进展率（HRP）和低进展率（LRP）；后一组包括无复发的患者。在一个独立的验证数据集中，优先排序的microrna区分了HRP和LRP，并与转移进展率和生存率相关。寡转移和多转移在临床和分子水平上是不同的实体。
Strategies to stage and treat cancer rely on a presumption of either localized or widespread metastatic disease. An intermediate state of metastasis termed oligometastasis(es) characterized by limited progression has been proposed. Oligometastases are amenable to treatment by surgical resection or radiotherapy. We analyzed microRNA expression patterns from lung metastasis samples of patients with ≤5 initial metastases resected with curative intent. Patients were stratified into subgroups based on their rate of metastatic progression. We prioritized microRNAs between patients with the highest and lowest rates of recurrence. We designated these as high rate of progression (HRP) and low rate of progression (LRP); the latter group included patients with no recurrences. The prioritized microRNAs distinguished HRP from LRP and were associated with rate of metastatic progression and survival in an independent validation dataset. Oligo- and poly- metastasis are distinct entities at the clinical and molecular level.
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