Alcohol and risk of Parkinson's disease in a large, prospective cohort of men and women.
Alcohol and risk of Parkinson's disease in a large, prospective cohort of men and women.
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DOI：
10.1002/mds.25050
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Ascherio AA
中科院分区：
文献类型：
--
作者：
Palacios N;Gao X;O'Reilly E;Schwarzschild M;McCullough ML;Mayo T;Gapstur SM;Ascherio AA
Addictive behaviors such as cigarette smoking and coffee drinking have been associated with a reduced risk of Parkinson disease. Whether alcohol consumption is also associated with risk is less certain. We prospectively followed 132,403 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2005. Alcohol intake was assessed at baseline. Incident cases of Parkinson Disease (n = 605; 389 male and 216 female) were confirmed by treating physicians and medical record review. Relative risks were estimated using proportional hazards models, adjusting for age, smoking and other risk factors. Alcohol consumption was not significantly associated with Parkinson Disease risk. After adjustment for age, smoking, and other risk factors, the Relative Risk comparing men consuming 30 or more grams of alcohol (highest category) to non-drinker men was 1.29 (95% CI: 0.90, 1.86, p-trend: 0.40) and the Relative Risk comparing women consuming 15 or more grams of alcohol (highest category) per day to non-drinker women was 0.77 (95% CI: 0.41, 1.45, p-trend: 0.87). Consumption of beer, wine or liquor was also not associated with Parkinson Disease risk. The results of this large prospective study do not support an association between alcohol intake and risk of Parkinson disease.
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