Vitiligo and alopecia areata: apples and oranges?
Vitiligo and alopecia areata: apples and oranges?
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DOI：
10.1111/exd.12264
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发表时间：
2013-12
影响因子：
3.6
通讯作者：
Harris JE
中科院分区：
文献类型：
--
作者：
Harris JE
白癜风和斑秃是常见的皮肤自身免疫性疾病。白癜风是由黑色素细胞的破坏引起的，并导致身体任何部位出现白色斑块，而斑秃的特征是主要在头皮上的斑片状脱发，但也可能涉及其他区域。乍一看，这两种疾病似乎完全不同，针对不同的细胞类型，并使用不同的治疗方法进行管理。然而，驱动每种疾病的免疫细胞群和细胞因子是相似的，它们在患者及其家庭成员中密切相关，白癜风和斑秃具有共同的遗传危险因素，表明它们具有相似的发病机制。就像苹果和橘子一样，白癜风和斑秃有一些明显的区别，但相似之处比比皆是。认识到相似性和差异性将促进对每种疾病发病机制的研究，以及新治疗方法的开发。
Vitiligo and alopecia areata are common autoimmune diseases of the skin. Vitiligo is caused by the destruction of melanocytes and results in the appearance of white patches on any part of the body, while alopecia areata is characterized by patchy hair loss primarily on the scalp, but may also involve other areas as well. At first glance, the two diseases appear to be quite different, targeting different cell types and managed using different treatment approaches. However, the immune cell populations and cytokines that drive each disease are similar, they are closely associated within patients and their family members, and vitiligo and alopecia areata have common genetic risk factors, suggesting that they share a similar pathogenesis. Like apples and oranges, vitiligo and alopecia areata have some obvious differences, but similarities abound. Recognizing both similarities and differences will promote research into the pathogenesis of each disease, as well as the development of new treatments.
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