Computational modelling suggests that temporal integration results from synaptic adaptation in auditory cortex
Computational modelling suggests that temporal integration results from synaptic adaptation in auditory cortex
复制标题
计算模型表明时间整合是听觉皮层突触适应的结果
DOI：
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发表时间：
2015
影响因子：
3.4
通讯作者：
H. Tiitinen
中科院分区：
文献类型：
--
作者：
P. May;Johan Westö;H. Tiitinen
传入的声音是在先前事件的上下文中表示的，这需要一种随时间整合信息的记忆机制。在这里，研究证明，反应适应，即由于刺激重复而抑制神经反应，可能反映了听觉皮层用于时间整合的计算解决方案。在单单元测量中观察到的适应是双音前向掩蔽效应和刺激特异性适应（SSA）。在非侵入性观察中，听觉 N1m 反应的幅度与刺激重复密切相关，随后对罕见的异常事件进行反应恢复（所谓的失配反应）。当前的计算模拟描述了听觉皮层的串行核心-带-副带结构，包括突触适应、兴奋性皮质连接的短期、活动依赖性抑制。研究发现，突触适应足以使柱选择性地响应音调对和复杂的音调序列。当对刺激序列的强烈响应与对时间反转序列和孤立序列元素的较弱响应相结合时，这些响应被定义为组合敏感，从而反映了时间整合。刺激的时间复杂性似乎反映在模型不同区域的组合敏感列的比例上。我们的结果表明，虽然突触适应产生促进和抑制效应，包括 SSA 和 N1m 反应的调节，但其功能意义实际上可能在于其对时间整合的贡献。这种整合似乎受益于听觉皮层的串行结构。
Incoming sounds are represented in the context of preceding events, and this requires a memory mechanism that integrates information over time. Here, it was demonstrated that response adaptation, the suppression of neural responses due to stimulus repetition, might reflect a computational solution that auditory cortex uses for temporal integration. Adaptation is observed in single‐unit measurements as two‐tone forward masking effects and as stimulus‐specific adaptation (SSA). In non‐invasive observations, the amplitude of the auditory N1m response adapts strongly with stimulus repetition, and it is followed by response recovery (the so‐called mismatch response) to rare deviant events. The current computational simulations described the serial core‐belt‐parabelt structure of auditory cortex, and included synaptic adaptation, the short‐term, activity‐dependent depression of excitatory corticocortical connections. It was found that synaptic adaptation is sufficient for columns to respond selectively to tone pairs and complex tone sequences. These responses were defined as combination sensitive, thus reflecting temporal integration, when a strong response to a stimulus sequence was coupled with weaker responses both to the time‐reversed sequence and to the isolated sequence elements. The temporal complexity of the stimulus seemed to be reflected in the proportion of combination‐sensitive columns across the different regions of the model. Our results suggest that while synaptic adaptation produces facilitation and suppression effects, including SSA and the modulation of the N1m response, its functional significance may actually be in its contribution to temporal integration. This integration seems to benefit from the serial structure of auditory cortex.
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DOI：
10.3109/00016489709126142
发表时间：
1997
期刊：
Acta oto-laryngologica. Supplementum
影响因子：
--
作者：
J. Rauschecker
通讯作者：
J. Rauschecker
影响因子：
2.5
作者：
Bartlett, EL;Wang, XQ
通讯作者：
Wang, XQ
影响因子：
2.5
作者：
Brosch, M;Schreiner, CE
通讯作者：
Schreiner, CE
影响因子：
3.7
作者：
Kurt S;Deutscher A;Crook JM;Ohl FW;Budinger E;Moeller CK;Scheich H;Schulze H
通讯作者：
Schulze H
DOI：
10.1016/s0013-4694(97)00043-6
发表时间：
1997-10-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Okada, YC;Wu, J;Kyuhou, S
通讯作者：
Kyuhou, S