Auditory cortical contrast enhancing by global winner-take-all inhibitory interactions.

Auditory cortical contrast enhancing by global winner-take-all inhibitory interactions.
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DOI:
10.1371/journal.pone.0001735
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发表时间:
2008-03-05
期刊:
影响因子:
3.7
通讯作者:
Schulze H
Schulze H
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Kurt S;Deutscher A;Crook JM;Ohl FW;Budinger E;Moeller CK;Scheich H;Schulze H

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大脑将世界分解为离散的感知对象,从而面临如何隔离和选择性地处理同时存在于场景中的类似对象的问题。理论模型提出,这可以通过所谓的赢家通吃算法的神经元实现来实现,其中对象或对象特征的神经元表示以竞争的方式相互作用。在这里,我们提出的证据,这种机制存在于动物物种。我们目前的电生理,神经药理学和神经解剖学数据,提出了一种新的观点GABAA介导的抑制在初级听觉皮层(AI)的作用,其中皮层内GABAA介导的抑制在全球范围内的声音周期性表示在AI的圆形地图,从任何位置在整个地图的功能抑制预测类似的效果。这些交互可以作为所提出的竞争性“赢家通吃”算法的基础,以支持对象隔离,例如,在鸡尾酒会上把不同的发言者隔离开来。
Brains decompose the world into discrete objects of perception, thereby facing the problem of how to segregate and selectively address similar objects that are concurrently present in a scene. Theoretical models propose that this could be achieved by neuronal implementations of so-called winner-take-all algorithms where neuronal representations of objects or object features interact in a competitive manner. Here we present evidence for the existence of such a mechanism in an animal species. We present electrophysiological, neuropharmacological and neuroanatomical data which suggest a novel view of the role of GABAA-mediated inhibition in primary auditory cortex (AI), where intracortical GABAA-mediated inhibition operates on a global scale within a circular map of sound periodicity representation in AI, with functionally inhibitory projections of similar effect from any location throughout the whole map. These interactions could underlie the proposed competitive “winner-take-all” algorithm to support object segregation, e.g., segregation of different speakers in cocktail-party situations.
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