Liquid Biopsy Biomarkers in Bladder Cancer: A Current Need for Patient Diagnosis and Monitoring.
Liquid Biopsy Biomarkers in Bladder Cancer: A Current Need for Patient Diagnosis and Monitoring.
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DOI：
10.3390/ijms19092514
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发表时间：
2018-08-24
影响因子：
5.6
通讯作者：
Suárez-Cabrera C
中科院分区：
文献类型：
--
作者：
Lodewijk I;Dueñas M;Rubio C;Munera-Maravilla E;Segovia C;Bernardini A;Teijeira A;Paramio JM;Suárez-Cabrera C
膀胱癌（BC）由于其高发病率和复发率以及有效疾病管理的有限进展而代表了临床和社会挑战。目前，细胞学和膀胱镜检查的组合是常规使用的诊断，预后和疾病监测的方法。然而，细胞学检查的敏感性差以及使用膀胱镜检查的肿瘤分期和分级解释的高侵入性和大变化，强调了迫切需要改进BC临床指导。液体活检代表了一种新的非侵入性方法，在过去十年中得到了广泛的研究，并具有很大的前景。尽管其临床应用仍然受到影响，但最近多项研究都集中在生物标志物在BC液体活检中的潜在应用，包括循环肿瘤细胞和DNA，RNA，蛋白质和肽，代谢物和细胞外囊泡。在这篇综述中，我们总结了目前的知识，不同类型的生物标志物，其潜在的液体活检和临床应用中的BC。
Bladder Cancer (BC) represents a clinical and social challenge due to its high incidence and recurrence rates, as well as the limited advances in effective disease management. Currently, a combination of cytology and cystoscopy is the routinely used methodology for diagnosis, prognosis and disease surveillance. However, both the poor sensitivity of cytology tests as well as the high invasiveness and big variation in tumour stage and grade interpretation using cystoscopy, emphasizes the urgent need for improvements in BC clinical guidance. Liquid biopsy represents a new non-invasive approach that has been extensively studied over the last decade and holds great promise. Even though its clinical use is still compromised, multiple studies have recently focused on the potential application of biomarkers in liquid biopsies for BC, including circulating tumour cells and DNA, RNAs, proteins and peptides, metabolites and extracellular vesicles. In this review, we summarize the present knowledge on the different types of biomarkers, their potential use in liquid biopsy and clinical applications in BC.
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影响因子：
4.5
作者：
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通讯作者：
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DOI：
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期刊：
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