Inhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo.
Inhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo.
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DOI：
10.1007/s10456-014-9445-2
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发表时间：
2015-01
期刊：
影响因子：
9.8
通讯作者：
Brooks, Peter C.
中科院分区：
文献类型：
--
作者：
Contois, Liangru W.;Akalu, Abebe;Caron, Jennifer M.;Tweedie, Eric;Cretu, Alexandra;Henderson, Terry;Liaw, Lucy;Friesel, Robert;Vary, Calvin;Brooks, Peter C.
A more complete understanding of the mechanisms that regulate the angiogenic switch, which contributes to the conversion of small dormant tumors to actively growing malignancies, is important for the development of more effective anti-angiogenic strategies for cancer therapy. While significant progress has been made in understanding the complex mechanisms by which integrin αvβ3 expressed in endothelial cells governs angiogenesis, less is known concerning the ability of αvβ3 expressed within the tumor cell compartment to modulate the angiogenic output of a tumor. Here we provide evidence that αvβ3 expressed in melanoma cells may contribute to the suppression of IGFBP-4, an important negative regulator of IGF-1 signaling. Given the multiple context-dependent roles for αvβ3 in angiogenesis and tumor progression, our novel findings provide additional molecular insight into how αvβ3 may govern the angiogenic switch by a mechanism associated with a p38 MAPK and matrix metalloproteinases-dependent regulation of the endogenous angiogenesis inhibitor IGFBP-4.
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影响因子：
64.5
作者：
BROOKS, PC;MONTGOMERY, AMP;CHERESH, DA
通讯作者：
CHERESH, DA
影响因子：
56.9
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BROOKS, PC;CLARK, RAF;CHERESH, DA
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CHERESH, DA
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分子机制和血管生成的临床应用。
影响因子：
64.8
作者：
Carmeliet, Peter;Jain, Rakesh K.
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Jain, Rakesh K.
影响因子：
14.5
作者：
Contois L;Akalu A;Brooks PC
通讯作者：
Brooks PC