Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era.
Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era.
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DOI：
10.3390/ijms23084359
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发表时间：
2022-04-14
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
最近针对SARS-CoV-2感染的mRNA疫苗的开发使人们关注到核酸作为创新预防剂和诊断和治疗工具的潜力。到目前为止，由于它们在生物环境中的半衰期缩短以及运输到靶细胞的困难，它们的使用受到严重限制。这些限制因素现在可以通过对药物进行化学修饰和使用适当的纳米载体来克服。寡核苷酸可以与核酸靶标的互补序列相互作用，形成稳定的复合物并决定其功能的丧失。另一种策略是使用核酸适体，像抗体一样，与特定蛋白质结合来调节其活性。在这篇综述中，作者将回顾最近关于COVID-19时代基于核酸的策略的文献，重点关注其在COVID-19预防中的应用，以及针对冠状病毒大流行的基于反义和适配体的策略。
The recent development of mRNA vaccines against the SARS-CoV-2 infection has turned the spotlight on the potential of nucleic acids as innovative prophylactic agents and as diagnostic and therapeutic tools. Until now, their use has been severely limited by their reduced half-life in the biological environment and the difficulties related to their transport to target cells. These limiting aspects can now be overcome by resorting to chemical modifications in the drug and using appropriate nanocarriers, respectively. Oligonucleotides can interact with complementary sequences of nucleic acid targets, forming stable complexes and determining their loss of function. An alternative strategy uses nucleic acid aptamers that, like the antibodies, bind to specific proteins to modulate their activity. In this review, the authors will examine the recent literature on nucleic acids-based strategies in the COVID-19 era, focusing the attention on their applications for the prophylaxis of COVID-19, but also on antisense- and aptamer-based strategies directed to the diagnosis and therapy of the coronavirus pandemic.
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DOI：
10.3390/nano11020523
发表时间：
2021-02-18
期刊：
Nanomaterials (Basel, Switzerland)
影响因子：
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作者：
Crisci T;Falanga AP;Casalino M;Borbone N;Terracciano M;Chianese G;Gioffrè M;D'Errico S;Marzano M;Rea I;De Stefano L;Oliviero G
通讯作者：
Oliviero G
影响因子：
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作者：
Amato, Felice;Tomaiuolo, Rossella;Castaldo, Giuseppe
通讯作者：
Castaldo, Giuseppe
DOI：
10.3390/life11030193
发表时间：
2021-02-28
期刊：
Life (Basel, Switzerland)
影响因子：
--
作者：
Byun J
通讯作者：
Byun J
影响因子：
5.6
作者：
Caterino M;Costanzo M;Fedele R;Cevenini A;Gelzo M;Di Minno A;Andolfo I;Capasso M;Russo R;Annunziata A;Calabrese C;Fiorentino G;D'Abbraccio M;Dell'Isola C;Fusco FM;Parrella R;Fabbrocini G;Gentile I;Castaldo G;Ruoppolo M
通讯作者：
Ruoppolo M
影响因子：
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作者：
Amato, Jussara;Stellato, Marco Ignazio;Giancola, Concetta
通讯作者：
Giancola, Concetta