Voxel-based dose calculation of radionuclide imaging and therapy for preclinical studies using GEANT4 Monte Carlo simulation
Voxel-based dose calculation of radionuclide imaging and therapy for preclinical studies using GEANT4 Monte Carlo simulation
复制标题
使用 GEANT4 蒙特卡罗模拟进行基于体素的放射性核素成像和治疗临床前研究剂量计算
DOI：
10.52547/ijrr.20.2.9
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Pinyuan Xu
中科院分区：
文献类型：
--
作者：
Huan Liu;Changran Geng;Xiaobin Tang;Lingling Tang;Xinping Li;Pinyuan Xu
背景：本研究旨在研究体素水平的剂量计算方法，并提高其在核医学中的计算效率，同时考虑动物特异性异质组织成分和放射性药物的生物分布。材料和方法：体素化的小鼠模型是根据真实的小鼠 CT 图像构建的，并使用 Monte Carlo GEANT4 代码进行模拟。根据真实小鼠的动态PET图像，通过蒙特卡罗模拟设定了放射性药物活度的真实分布。提出了提高计算效率的采样方法。本研究采用了两种体素水平剂量计算方法。分别采用所提出的体素水平剂量计算方法和传统的MIRD方法计算重要靶器官和肿瘤的平均吸收剂量。比较两种方法计算的平均吸收剂量的结果。基于体素级剂量计算方法，获得并评估器官和肿瘤的三维剂量分布。结果：两种体素级剂量计算方法的平均吸收剂量相对差异大多小于10%。为提高体素级剂量计算的计算效率而提出的采样方法可以将计算时间减少约34%，且偏差较小。结论：结果证实，本研究提出的体素级剂量计算方法可以更准确、更有效地评估内部辐射剂量。
Background : This study aims to investigate voxel - level dose calculation methods and improve its calculation efficiency in nuclear medicine that can consider animal - specific heterogeneous tissue compositions and radiopharmaceutical biodistributions simultaneously. Materials and Methods : The voxelized mouse phantom was constructed from real mouse CT images and simulated using the Monte Carlo GEANT4 code. According to the dynamic PET images of real mouse, the real distribution of radiopharmaceutical activity was set in the Monte Carlo simulation. The sampling method to improve the calculation efficiency was proposed. Two voxel - level dose calculation methods were implemented in this study. The average absorbed dose in vital target organs and the tumor was calculated by the proposed voxel - level dose calculation methods and the traditional MIRD method respectively. The results of the average absorbed dose calculated by the two methods were compared. Based on the voxel - level dose calculation method, the three - dimensional dose distribution in organs and the tumor was obtained and evaluated . Results : The relative difference of average absorbed dose between the two voxel - level dose calculation methods was mostly less than 10%. The sampling method proposed to improve calculation efficiency for the voxel - level dose calculation can decrease the calculation time by ~34% with less deviation. Conclusion : The results confirmed that the voxel - level dose calculation methods proposed in this study allow for more accurate and efficient assessment of the internal radiation dose.
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影响因子：
9.3
作者：
Lee, Min Sun;Kim, Joong Hyun;Lee, Jae Sung
通讯作者：
Lee, Jae Sung
DOI：
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发表时间：
1999
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
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DOI：
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发表时间：
1971
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
2003-05
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
K. Kolbert;Timotheus Watson;C. Matei;Su Xu;J. Koutcher;G. Sgouros
通讯作者：
K. Kolbert;Timotheus Watson;C. Matei;Su Xu;J. Koutcher;G. Sgouros
DOI：
10.1016/j.ejmp.2020.04.010
发表时间：
2020-04
期刊：
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics
影响因子：
--
作者：
A. Frezza;Charles Joachim-Paquet;M. Chauvin;P. Després
通讯作者：
A. Frezza;Charles Joachim-Paquet;M. Chauvin;P. Després