Rapid effects of estrogens on behavior: environmental modulation and molecular mechanisms.

Rapid effects of estrogens on behavior: environmental modulation and molecular mechanisms.
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DOI:
10.1016/j.yfrne.2014.03.005
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发表时间:
2014-10
影响因子:
7.4
通讯作者:
Trainor, Brian C.
Trainor, Brian C.
中科院分区:
医学1区
文献类型:
--
作者:
Laredo, Sarah A.;Landeros, Rosalina Villalon;Trainor, Brian C.

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雌激素可以通过基因组和非基因组机制调节神经活动和行为。环境线索对这些信号通路的相对重要性有重大影响,并对行为产生重大影响。首先,我们考虑光周期如何调节非基因组雌激素信号传导的行为。有趣的是,短日照使得雌激素对啮齿类动物和鸣禽麻雀的攻击性产生快速影响。这突出了在实验室研究中将光周期作为一个变量的重要性。接下来,我们回顾了雌二醇对生态相关行为(包括攻击、交配、交流和学习)的快速影响的证据。我们还讨论了内分泌干扰物对雌激素信号的影响,例如在啮齿动物研究中使用的玉米芯垫料中发现的内分泌干扰物。最后,我们研究的生化机制,可能介导快速雌激素作用的行为在男性和女性。这些主题的一个共同主题是雌激素对社会行为的影响在不同的环境条件下各不相同。
Estradiol can modulate neural activity and behavior via both genomic and nongenomic mechanisms. Environmental cues have a major impact on the relative importance of these signaling pathways with significant consequences for behavior. First we consider how photoperiod modulates nongenomic estrogen signaling on behavior. Intriguingly, short days permit rapid effects of estrogens on aggression in both rodents and song sparrows. This highlights the importance of considering photoperiod as a variable in laboratory research. Next we review evidence for rapid effects of estradiol on ecologically-relevant behaviors including aggression, copulation, communication, and learning. We also address the impact of endocrine disruptors on estrogen signaling, such as those found in corncob bedding used in rodent research. Finally, we examine the biochemical mechanisms that may mediate rapid estrogen action on behavior in males and females. A common theme across these topics is that the effects of estrogens on social behaviors vary across different environmental conditions.
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