Change of Nrf2 expression in rat hippocampus in a model of chronic cerebral hypoperfusion
Change of Nrf2 expression in rat hippocampus in a model of chronic cerebral hypoperfusion
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慢性脑低灌注模型大鼠海马Nrf2表达变化
DOI：
10.3109/00207454.2013.863196
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发表时间：
2014-08
影响因子：
2.2
通讯作者：
张磊
中科院分区：
文献类型：
--
作者：
章军建;杨英;刘晖;张磊
慢性脑灌注不足（CCH）在血管性痴呆和阿尔茨海默病中很常见。CCH相关的氧化损伤在认知障碍的发展中起着重要作用。核因子-红细胞2相关因子2（Nrf 2）介导抗氧化反应元件（ARE）相关基因表达的激活，这对内源性抗氧化系统至关重要。在这种情况下，我们使用永久性双侧颈总动脉闭塞（2 VO）来模拟CCH。检测海马不同区域Nrf 2的表达以及核Nrf 2与ARE结合的能力。已经观察到DNA结合活性下调的现象。有趣的是，在2 VO手术后3周内，大鼠海马大部分区域的Nrf 2表达显著升高。这种不匹配可能是由于Nrf 2功能障碍和代偿性合成所致。结论：Nrf 2功能障碍是导致CCH所致氧化损伤的重要因素，Nrf 2可作为一个有希望的靶点来减轻CCH所致的氧化损伤，甚至认知功能障碍。
Chronic cerebral hypoperfusion (CCH) is common in vascular dementia and Alzheimer's disease. CCH-related oxidative damage plays a significant role in the development of cognitive impairment. Nuclear factor-erythroid 2-related factor-2 (Nrf2) mediates activation of the antioxidant responsive element (ARE)-related gene expression, which is crucial to the endogenous antioxidative system. In this case, we used permanent bilateral occlusion of common carotid arteries (2VO) to mimic CCH. The expression of Nrf2 in different regions of the hippocampus as well as the ability of nuclear Nrf2 and ARE binding have been examined. A phenomenon has been observed that the DNA binding activities were down-regulated. Interestingly, the expression of Nrf2 rose significantly in most regions of rat hippocampus within three weeks after the 2VO surgery. The mismatch might attribute to Nrf2 dysfunction and compensatory synthesis. A conclusion can be drawn that Nrf2 dysfunction is an important factor as a cause of CCH-induced oxidative damage and Nrf2 can be treated as a promising target to alleviate oxidative damage, even cognitive impairment caused by CCH.
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影响因子：
3.3
作者：
Barhwal, K.;Hota, S. K.;Ilavazhagan, G.
通讯作者：
Ilavazhagan, G.
影响因子：
10.5
作者：
Itoh, K;Wakabayashi, N;Yamamoto, M
通讯作者：
Yamamoto, M
DOI：
10.1046/j.1440-1681.2003.03825.x
发表时间：
2003-04-01
影响因子：
2.9
作者：
Otori, T;Katsumata, T;Terashi, A
通讯作者：
Terashi, A
影响因子：
5.2
作者：
Johnson, Jeffrey A.;Johnson, Delinda A.;Kraft, Andrew D.;Calkins, Marcus J.;Jakel, Rebekah J.;Vargas, Marcelo R.;Chen, Pei-Chun
通讯作者：
Chen, Pei-Chun
影响因子：
8.2
作者：
Y. Liao;Rui Wang;Xi-can Tang
通讯作者：
Y. Liao;Rui Wang;Xi-can Tang