Preclinical neurorehabilitation with environmental enrichment confers cognitive and histological benefits in a model of pediatric asphyxial cardiac arrest.
Preclinical neurorehabilitation with environmental enrichment confers cognitive and histological benefits in a model of pediatric asphyxial cardiac arrest.
复制标题
DOI：
10.1016/j.expneurol.2020.113522
复制
发表时间：
2021-01
影响因子：
5.3
通讯作者：
Kline AE
中科院分区：
文献类型：
--
作者：
Manole MD;Hook MJA;Nicholas MA;Nelson BP;Liu AC;Stezoski QC;Rowley AP;Cheng JP;Alexander H;Moschonas EH;Bondi CO;Kline AE
Pediatric asphyxial cardiac arrest (ACA) often leaves children with physical, cognitive, and emotional disabilities that affect overall quality of life, yet rehabilitation is neither routinely nor systematically provided. Environmental enrichment (EE) is considered a preclinical model of neurorehabilitation and thus we sought to investigate its efficacy in our established model of pediatric ACA. Male Sprague-Dawley rat pups (post-natal day 16–18) were randomly assigned to ACA (9.5 min) or Sham injury. After resuscitation, the rats were assigned to 21 days of EE or standard (STD) housing during which time motor, cognitive, and anxiety-like (i.e., affective) outcomes were assessed. Hippocampal CA1 cells were quantified on post-operative day-22. Both ACA + STD and ACA + EE performed worse on beam-balance vs. Sham controls (p<0.05) and did not differ from one another overall (p>0.05); however, a single day analysis on the last day of testing revealed that the ACA + EE group performed better than the ACA + STD group (p<0.05) and did not differ from the Sham controls (p>0.05). Both Sham groups performed better than ACA + STD (p<0.05) but did not differ from ACA + EE (p>0.05) in the open field test. Spatial learning and declarative memory were improved and CA1 neuronal loss was attenuated in the ACA + EE vs. ACA + STD group (p<0.05). Collectively, the data suggest that providing rehabilitation after pediatric ACA can reduce histopathology and improve motor and cognitive ability.
登录
查看更多内容
影响因子：
6.2
作者：
Donoghue, AJ;Nadkarni, V;Stiell, IG
通讯作者：
Stiell, IG
影响因子：
2.7
作者：
Goncalves, Lara Vezula;Herlinger, Alice Laschuk;Martins-Silva, Cristina
通讯作者：
Martins-Silva, Cristina
影响因子：
6.3
作者：
Manole, Mioara D.;Kochanek, Patrick M.;Clark, Robert S. B.
通讯作者：
Clark, Robert S. B.
影响因子：
6.1
作者：
Inacio, Ana R.;Ruscher, Karsten;Wieloch, Tadeusz
通讯作者：
Wieloch, Tadeusz
影响因子：
2.5
作者：
Briones, T L;Therrien, B;Metzger, B
通讯作者：
Metzger, B