Experimental validation of the influence of white matter anisotropy on the intracranial EEG forward solution.
Experimental validation of the influence of white matter anisotropy on the intracranial EEG forward solution.
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DOI：
10.1007/s10827-009-0205-z
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发表时间：
2010-12
影响因子：
1.2
通讯作者：
Halgren E
中科院分区：
文献类型：
--
作者：
Bangera NB;Schomer DL;Dehghani N;Ulbert I;Cash S;Papavasiliou S;Eisenberg SR;Dale AM;Halgren E
具有不同复杂程度的正向解被用于电流发生器的定位，电流发生器负责从人脑测量的电场和磁场。大脑各向异性对正解的影响知之甚少。本研究的目的是通过与直接测量的“金标准”进行比较来验证颅内电正演解的各向异性模型。在大脑中的已知位置处创建双极源，同时记录颅内脑电图（EEG）。沿着生成复杂度不断增加的各向同性模型和基于扩散张量成像（DTI）的各向异性模型。基于有限元法的正解计算和验证使用的实测数据。主要研究结果如下：（1）验证了脑组织电导率张量和水扩散张量特征值之间存在线性比例关系的各向异性模型。当刺激部位接近高各向异性区域时，获得最大的改善。在所有各向异性模型中，特征值之间的全局各向异性比为10：1（平行于纤维方向：与纤维方向相切）的模型具有最差的性能。(2)包括脑脊液以及大脑各向异性的前向模型是必要的准确描述的电场内的头骨。结果表明，各向异性模型的基础上的DTI可以构建非侵入性的，并表现出改善的性能相比，各向同性模型的颅内脑电正解的计算。本文的在线版本（doi：10.1007/s10827-009-0205-z）包含补充材料，可供授权用户使用。
Forward solutions with different levels of complexity are employed for localization of current generators, which are responsible for the electric and magnetic fields measured from the human brain. The influence of brain anisotropy on the forward solution is poorly understood. The goal of this study is to validate an anisotropic model for the intracranial electric forward solution by comparing with the directly measured ‘gold standard’. Dipolar sources are created at known locations in the brain and intracranial electroencephalogram (EEG) is recorded simultaneously. Isotropic models with increasing level of complexity are generated along with anisotropic models based on Diffusion tensor imaging (DTI). A Finite Element Method based forward solution is calculated and validated using the measured data. Major findings are (1) An anisotropic model with a linear scaling between the eigenvalues of the electrical conductivity tensor and water self-diffusion tensor in brain tissue is validated. The greatest improvement was obtained when the stimulation site is close to a region of high anisotropy. The model with a global anisotropic ratio of 10:1 between the eigenvalues (parallel: tangential to the fiber direction) has the worst performance of all the anisotropic models. (2) Inclusion of cerebrospinal fluid as well as brain anisotropy in the forward model is necessary for an accurate description of the electric field inside the skull. The results indicate that an anisotropic model based on the DTI can be constructed non-invasively and shows an improved performance when compared to the isotropic models for the calculation of the intracranial EEG forward solution. The online version of this article (doi:10.1007/s10827-009-0205-z) contains supplementary material, which is available to authorized users.
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影响因子：
3.5
作者：
Latikka, J;Kuurne, T;Eskola, H
通讯作者：
Eskola, H
DOI：
10.1016/s0013-4694(98)00057-1
发表时间：
1998-08-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Leahy, RM;Mosher, JC;Lewine, JD
通讯作者：
Lewine, JD
影响因子：
2.7
作者：
Law, Samuel K.
通讯作者：
Law, Samuel K.
影响因子：
4.7
作者：
Cuffin, BN;Schomer, DL;Blume, H
通讯作者：
Blume, H
影响因子：
5.3
作者：
NICHOLSON, PW
通讯作者：
NICHOLSON, PW