Serum Urate and Risk of Chronic Kidney Disease: A Mendelian Randomization Study Using Taiwan Biobank.
Serum Urate and Risk of Chronic Kidney Disease: A Mendelian Randomization Study Using Taiwan Biobank.
复制标题
血清尿酸与慢性肾脏病的风险：使用台湾生物银行的孟德尔随机研究。
DOI：
10.1016/j.mayocp.2023.01.004
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发表时间：
2023
影响因子：
8.9
通讯作者：
Yung
中科院分区：
文献类型：
--
作者：
Hsiao;T. Lai;Yi;Chia;Y. Chou;Vincet Wu;Shuei;Yung
目的探讨血尿酸与慢性肾脏病(CKD)发病风险之间的关系，以及血尿酸在慢性肾脏病发病中的作用。方法采用前瞻性队列研究和孟德尔随机分析方法，对台湾生物资料库2012年1月1日至2021年12月31日的纵向资料进行分析。经过中位数(四分位数范围)4.1(3.1-4.9)年的随访，429名参与者发展为慢性肾脏病。在调整了年龄、性别和合并疾病后，血尿酸每增加一毫克/分升，发生慢性肾脏病的风险增加15%(HR，1.15；95%CI，1.08至1.24；P<；.001)。遗传风险评分和7种孟德尔随机化方法显示，血尿酸水平与CKD发病风险之间无显著相关性(HR，1.03；95%CI，0.72~1.46；P=0.89；7种孟德尔随机化方法均为0.05)。结论这项基于人群的前瞻性队列研究显示，血尿酸升高是发生CKD的重要危险因素；然而，孟德尔随机化分析未能提供证据表明血尿酸对东亚人群CKD有因果影响。
ObjectiveTo evaluate the association between serum urate and risk of incident chronic kidney disease (CKD) and to assess whether serum urate plays a causal role in CKD.Patients and MethodsWe conducted a prospective cohort study and Mendelian randomization analysis that analyzed longitudinal data from the Taiwan Biobank between January 1, 2012, and December 31, 2021.ResultsA total of 34,831 individuals met the inclusion criteria, of which 4697 (13.5%) had hyperuricemia. After a median (interquartile range) follow-up of 4.1 (3.1-4.9) years, 429 participants developed CKD. After adjustment for age, sex, and comorbid conditions, each mg/dL increase in serum urate was associated with a 15% higher risk of incident CKD (HR, 1.15; 95% CI, 1.08 to 1.24;P<.001). The genetic risk score and seven Mendelian randomization methods revealed no significant association between serum urate levels and the risk of incident CKD (HR, 1.03; 95% CI, 0.72 to 1.46;P=0.89; allP>.05 for 7 Mendelian randomization methods).ConclusionThis prospective, population-based cohort study showed that elevated serum urate is a significant risk factor for incident CKD; however, Mendelian randomization analyses failed to provide evidence that serum urate had a causal effect on CKD in the East Asian population.
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影响因子：
5
作者：
Juraschek, Stephen P.;Kovell, Lara C.;Miller, Edgar R., III;Gelber, Allan C.
通讯作者：
Gelber, Allan C.
DOI：
10.1053/j.ajkd.2017.12.009
发表时间：
2018-06
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Johnson RJ;Bakris GL;Borghi C;Chonchol MB;Feldman D;Lanaspa MA;Merriman TR;Moe OW;Mount DB;Sanchez Lozada LG;Stahl E;Weiner DE;Chertow GM
通讯作者：
Chertow GM
影响因子：
19.6
作者：
Hughes K;Flynn T;de Zoysa J;Dalbeth N;Merriman TR
通讯作者：
Merriman TR
影响因子：
39.2
作者：
Levey AS;Stevens LA;Schmid CH;Zhang YL;Castro AF 3rd;Feldman HI;Kusek JW;Eggers P;Van Lente F;Greene T;Coresh J;CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
通讯作者：
CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
影响因子：
9.8
作者：
Purcell, Shaun;Neale, Benjamin;Sham, Pak C.
通讯作者：
Sham, Pak C.