Association of kidney disease with prevalent gout in the United States in 1988-1994 and 2007-2010.
Association of kidney disease with prevalent gout in the United States in 1988-1994 and 2007-2010.
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DOI：
10.1016/j.semarthrit.2012.09.009
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发表时间：
2013-06
影响因子：
5
通讯作者：
Gelber, Allan C.
中科院分区：
文献类型：
--
作者：
Juraschek, Stephen P.;Kovell, Lara C.;Miller, Edgar R., III;Gelber, Allan C.
确定美国人群中与肾脏疾病进展程度相关的痛风患病率。我们对1988-1994年和2007-2010年国家健康和营养检查调查的非机构化成年人（20岁及以上）进行了横断面分析。痛风状态通过医生诊断的痛风患者的自我报告确定。慢性肾脏疾病（CKD）根据估计的肾小球滤过率（GFR）和单次白蛋白尿测量值（白蛋白/肌酐比值）分期定义。通过Poisson回归确定GFR、白蛋白尿和CKD的患病率比以及22年时间间隔内的时间趋势。在美国，痛风的粗患病率在无CKD的参与者中为2-3%，在CKD 1期的参与者中为4%，2期为6-10%，3期为11-13%，4期超过30%。2007-2010年，CKD 4期分层与无CKD参与者的校正患病率比为3.20（95% CI：1.96，5.24），即使在校正血清尿酸后仍显着。值得注意的是，有一个统计学上显著的，逐步更大的调整后的痛风患病率与连续较低类别的GFR和较高类别的蛋白尿。在美国成年人中，肾功能受损和痛风流行之间存在强烈的剂量反应相关性。健康提供者应该意识到CKD患者痛风负担的增加，特别是在评估新发关节疼痛和肿胀时。
To determine the prevalence of gout associated with progressive degrees of kidney disease in the US population. We performed a cross-sectional analysis among non-institutionalized adults (age 20 and older) of the National Health and Nutrition Examination Surveys in 1988–1994 and 2007–2010. Gout status was ascertained by self-report of physician-diagnosed gout. Chronic kidney disease (CKD) was defined in stages based on estimated glomerular filtration rate (GFR) and single albuminuria measurements (albumin-to-creatinine ratio). Prevalence ratios comparing successive categories of GFR, albuminuria, and CKD as well as temporal trends over a 22-year interval were determined via Poisson regression. In the US, the crude prevalence of gout was 2–3% among participants without CKD, 4% among participants with CKD stage 1, 6–10% for stage 2, 11–13% for stage 3, and over 30% for stage 4. The adjusted prevalence ratio comparing the CKD stage 4 stratum to participants without CKD was 3.20 (95% CI: 1.96, 5.24) in 2007–2010 and remained significant even after adjustment for serum uric acid. Notably, there was a statistically significant, progressively greater adjusted prevalence ratio of gout associated with successively lower categories of GFR and higher categories of albuminuria. Among US adults, there exists a strong dose–response association between impaired renal function and prevalent gout. Health providers should be aware of the elevated burden of gout among patients with CKD especially when evaluating new onset joint pain and swelling.
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影响因子：
13.2
作者：
Iseki, K;Ikemiya, Y;Takishita, S
通讯作者：
Takishita, S
DOI：
10.1002/art.22466
发表时间：
2007-02-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Choi, Hyon K.;Ford, Earl S.;Curhan, Gary
通讯作者：
Curhan, Gary
DOI：
10.3899/jrheum.100418
发表时间：
2011-01
期刊：
The Journal of rheumatology
影响因子：
--
作者：
McAdams MA;Maynard JW;Baer AN;Köttgen A;Clipp S;Coresh J;Gelber AC
通讯作者：
Gelber AC
影响因子：
120.7
作者：
Egan, Brent M.;Zhao, Yumin;Axon, R. Neal
通讯作者：
Axon, R. Neal
影响因子：
5
作者：
Lipkowitz, Michael S.
通讯作者：
Lipkowitz, Michael S.