Evaluating the use of optical coherence tomography for the detection of epithelial cancers in vitro.
Evaluating the use of optical coherence tomography for the detection of epithelial cancers in vitro.
复制标题
评估光学相干断层扫描在体外检测上皮癌中的应用。
DOI：
10.1117/1.3652708
复制
发表时间：
2011
影响因子：
3.5
通讯作者：
Smith LE
中科院分区：
文献类型：
--
作者：
Smith LE
Optical coherence tomography (OCT) is a noninvasive imaging methodology that is able to image tissue to depths of over 1 mm. Many epithelial conditions, such as melanoma and oral cancers, require an invasive biopsy for diagnosis. A noninvasive, real-time, point of care method of imaging depth-resolved epithelial structure could greatly improve early diagnosis and long-term monitoring in patients. Here, we have used tissue-engineered (TE) models of normal skin and oral mucosa to generate models of melanoma and oral cancer. We have used these to determine the ability of OCT to image epithelial differencesin vitro.We report that whilein vivoOCT gives reasonable depth information for both skin and oral mucosa,in vitrothe information provided is less detailed but still useful. OCT can provide reassurance on the development of TE models of skin and oral mucosa as they developin vitro. OCT was able to detect the gross alteration in the epithelium of skin and mucosal models generated with malignant cell lines but was less able to detect alteration in the epithelium of TE models that mimicked oral dysplasia or, in models where tumor cells had penetrated into the dermis.
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光学相干断层扫描可以可靠地识别喉上皮发育不良并进行精确的活检：对 61 名接受显微喉镜检查的患者进行的临床病理学研究
DOI：
--
发表时间：
2010
期刊：
The Laryngoscope
影响因子：
--
作者：
T. Just;E. Lankenau;F. Prall;G. Hüttmann;Hans;K. Sommer
通讯作者：
K. Sommer
离体和体内 OCT 图像对比
影响因子：
3.1
作者：
N. Krstajić;J. Jacobs;M. Bonesi;L. Smith;P. Deshpande;S. Macneil;R. Smallwood;S. Matcher
通讯作者：
S. Matcher
使用扫频光学相干断层扫描监测组织工程皮肤的伤口愈合情况
DOI：
--
发表时间：
2010
期刊：
BiOS
影响因子：
--
作者：
Louise E. Smith;Zenghai Lu;Marco Bonesi;Rod Smallwood;S. Matcher;Sheila MacNeil
通讯作者：
Sheila MacNeil
与口腔发育不良进展和获得永生相关的分子变化：5-氮杂胞苷逆转其的潜力。
影响因子：
11.2
作者：
F. McGregor;A. Muntoni;J. Fleming;Judith Brown;D. Felix;D. Macdonald;E. Parkinson;P. Harrison
通讯作者：
P. Harrison
影响因子：
2.5
作者：
Smith, Louise E.;Smallwood, Rod;Macneil, Sheila
通讯作者：
Macneil, Sheila