Colorectal cancer screening with odour material by canine scent detection.
Colorectal cancer screening with odour material by canine scent detection.
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DOI：
10.1136/gut.2010.218305
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发表时间：
2011-06
期刊：
影响因子：
24.5
通讯作者：
Maehara Y
中科院分区：
文献类型：
--
作者：
Sonoda H;Kohnoe S;Yamazato T;Satoh Y;Morizono G;Shikata K;Morita M;Watanabe A;Morita M;Kakeji Y;Inoue F;Maehara Y
早发现、早治疗是各种癌症成功治疗的关键。需要开发一种新的筛查方法，与粪便潜血试验(FOBT)一样经济和非侵入性地用于结直肠癌(CRC)的早期检测。一项利用犬类气味检测来确定气味材料是否可以成为结直肠癌筛查的有效工具的研究已经进行。呼气和水样粪便样本来自结肠镜检查前的结直肠癌患者和健康对照。每个试验组包括一名结直肠癌患者的样本和四名非癌症志愿者的对照样本。这五个样本被随机分开放入五个盒子中。一只专门接受过癌症嗅觉检测训练的拉布拉多猎犬和一名训练员在测试中进行了合作。这只狗首先闻到了一名CRC患者的标准呼气样本，然后闻了闻每个采样站，然后坐在检测到癌症气味的采样站前。对33组呼气样本和37组水样进行了检测。在结直肠癌患者和对照组中，呼气样本犬气味检测与结肠镜常规诊断相比的敏感性为0.91，特异性为0.99。粪便标本犬味检测的灵敏度为0.97，特异度为0.99。即使对于早期癌症，犬类气味检测的准确率也很高。犬类气味检测不会受到当前吸烟、良性结直肠疾病或炎症性疾病的干扰。这项研究表明，一种特定的癌症气味确实存在，而且癌症特有的化合物可能在全身循环。这些气味材料可能成为结直肠癌筛查的有效工具。在未来，旨在识别癌症特有的挥发性有机化合物的研究将对开发早期发现结直肠癌的新方法具有重要意义。
Early detection and early treatment are of vital importance to the successful treatment of various cancers. The development of a novel screening method that is as economical and non-invasive as the faecal occult blood test (FOBT) for early detection of colorectal cancer (CRC) is needed. A study was undertaken using canine scent detection to determine whether odour material can become an effective tool in CRC screening. Exhaled breath and watery stool samples were obtained from patients with CRC and from healthy controls prior to colonoscopy. Each test group consisted of one sample from a patient with CRC and four control samples from volunteers without cancer. These five samples were randomly and separately placed into five boxes. A Labrador retriever specially trained in scent detection of cancer and a handler cooperated in the tests. The dog first smelled a standard breath sample from a patient with CRC, then smelled each sample station and sat down in front of the station in which a cancer scent was detected. 33 and 37 groups of breath and watery stool samples, respectively, were tested. Among patients with CRC and controls, the sensitivity of canine scent detection of breath samples compared with conventional diagnosis by colonoscopy was 0.91 and the specificity was 0.99. The sensitivity of canine scent detection of stool samples was 0.97 and the specificity was 0.99. The accuracy of canine scent detection was high even for early cancer. Canine scent detection was not confounded by current smoking, benign colorectal disease or inflammatory disease. This study shows that a specific cancer scent does indeed exist and that cancer-specific chemical compounds may be circulating throughout the body. These odour materials may become effective tools in CRC screening. In the future, studies designed to identify cancer-specific volatile organic compounds will be important for the development of new methods for early detection of CRC.
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影响因子：
9.3
作者：
Manfredi, S.;Piette, C.;Bretagne, J. -F.
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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120.7
作者：
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通讯作者：
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影响因子：
24.5
作者：
Kievit, W;de Bruin, JHFM;Hoogerbrugge, N
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