Prospective observational study of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck.
Prospective observational study of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck.
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DOI：
10.1111/cas.13325
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发表时间：
2017-10
期刊：
影响因子：
5.7
通讯作者：
Working Group on Head and Neck Tumors
中科院分区：
文献类型：
--
作者：
Shirai K;Saitoh JI;Musha A;Abe T;Kobayashi D;Takahashi T;Tamaki T;Kawamura H;Takayasu Y;Shino M;Toyoda M;Takahashi K;Hirato J;Yokoo S;Chikamatsu K;Ohno T;Nakano T;Working Group on Head and Neck Tumors
为评价碳离子放疗治疗头颈部非鳞状细胞癌的有效性和安全性，本前瞻性研究入组了35例患者。主要终点是3年局部控制率，次要终点包括3年总生存率和不良事件。根据不良事件通用术语标准第4.0版评价急性和晚期不良事件。所有患者的中位随访时间为39个月。32例和3例患者分别接受了64.0戈伊（相对生物学有效性）和57.6戈伊（相对生物学有效性）的16次治疗。腺样囊性癌占60%。4例局部复发，5例死亡。3年局部控制率和总生存率分别为93%和88%。急性2-3级放射性粘膜炎（65%）和皮炎（31%）常见，经保守治疗后立即好转。分别在11例、1例和0例患者中观察到2级、3级和4级晚期粘膜炎。未发生5级不良事件。碳离子放射治疗对非鳞状细胞癌的局部控制和总生存率都很好。然而，晚期粘膜不良事件并不罕见，需要精心的治疗计划。试验注册号UMIN 000007886。
To evaluate the efficacy and safety of carbon‐ion radiotherapy for non‐squamous cell carcinoma of the head and neck, 35 patients were enrolled in this prospective study. The primary end‐point was the 3‐year local control rate, and the secondary end‐points included the 3‐year overall survival rate and adverse events. Acute and late adverse events were evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. The median follow‐up time for all patients was 39 months. Thirty‐two and three patients received 64.0 Gy (relative biological effectiveness) and 57.6 Gy (relative biological effectiveness) in 16 fractions, respectively. Adenoid cystic carcinoma was dominant (60%). Four patients had local recurrence and five patients died. The 3‐year local control and overall survival rates were 93% and 88%, respectively. Acute grade 2–3 radiation mucositis (65%) and dermatitis (31%) was common, which improved immediately with conservative therapy. Late mucositis of grade 2, grade 3, and grade 4 were observed in 11, one, and no patients, respectively. There were no adverse events of grade 5. Carbon‐ion radiotherapy achieved excellent local control and overall survival rates for non‐squamous cell carcinoma. However, the late mucosal adverse events were not rare, and meticulous treatment planning is required. Trial registration no. UMIN000007886.
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DOI：
10.1186/1748-717x-9-92
发表时间：
2014-04-03
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Sasahara G;Koto M;Ikawa H;Hasegawa A;Takagi R;Okamoto Y;Kamada T
通讯作者：
Kamada T
影响因子：
3.7
作者：
Musha A;Shimada H;Shirai K;Saitoh J;Yokoo S;Chikamatsu K;Ohno T;Nakano T
通讯作者：
Nakano T
DOI：
10.1016/j.ijrobp.2004.02.067
发表时间：
2004-10-01
影响因子：
7
作者：
Mizoe, J;Tsujii, H;Konno, A
通讯作者：
Konno, A
影响因子：
4.8
作者：
van Weert, Stijn;Bloemena, Elisabeth;Leemans, C. Rene
通讯作者：
Leemans, C. Rene
DOI：
10.1002/hed.21688
发表时间：
2012-02-01
影响因子：
2.9
作者：
Leonhardt, Fernando Danelon;Quon, Harry;Weinstein, Gregory S.
通讯作者：
Weinstein, Gregory S.