Renal threshold for glucose reabsorption predicts diabetes improvement by sodium-glucose cotransporter 2 inhibitor therapy.
Renal threshold for glucose reabsorption predicts diabetes improvement by sodium-glucose cotransporter 2 inhibitor therapy.
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DOI：
10.1111/jdi.12473
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发表时间：
2016-09
影响因子：
3.2
通讯作者：
Yamada M
中科院分区：
文献类型：
--
作者：
Osaki A;Okada S;Saito T;Yamada E;Ono K;Niijima Y;Hoshi H;Yamada M
在本研究中，我们检查了钠-葡萄糖协同转运蛋白 2 抑制剂对 2 型糖尿病患者糖化血红蛋白 (HbA1c) 改善的功效，并与葡萄糖重吸收的肾阈值进行了比较。患者每月到医院进行一次定期随访检查，测定血糖和 HbA1c 水平，并从点尿样本中测定尿糖浓度。比较伊格列净给药前后的患者样本。我们将葡萄糖重吸收的肾脏阈值定义为与首次可检测到的尿糖出现相关的最低血糖水平。这些数据显示，在接受钠-葡萄糖协同转运蛋白 2 抑制剂治疗的患者中，HbA1c 水平的改善与葡萄糖重吸收的肾脏阈值之间存在显着的负相关。这些发现表明，葡萄糖重吸收肾阈值较高的患者有望在降低 HbA1c 水平方面对钠-葡萄糖协同转运蛋白 2 抑制剂治疗产生更有效的反应。
In the present study we examined the efficacy of sodium‐glucose cotransporter 2 inhibitors on improvement of glycated hemoglobin (HbA1c) in comparison with the renal threshold for glucose reabsorption in patients with type 2 diabetes mellitus. Patients visited the hospital once a month for a regular follow‐up examination with the determination of blood glucose and HbA1c levels, and urinary glucose concentration from spot urine samples. Patient samples were compared before and after ipragliflozin administration. We defined the renal threshold for glucose reabsorption as the lowest blood glucose level that correlated with the first detectable appearance of urine glucose. These data showed a significant negative correlation between improvement of HbA1c level and renal threshold for glucose reabsorption in patients treated with the sodium‐glucose cotransporter 2 inhibitor. These findings show that patients who have a higher renal threshold for glucose reabsorption can be expected to more effectively respond to sodium‐glucose cotransporter 2 inhibitor therapy in terms of lowering HbA1c levels.
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