Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34).
Cloning and expression of feline colony stimulating factor receptor (CSF-1R) and analysis of the species specificity of stimulation by colony stimulating factor-1 (CSF-1) and interleukin-34 (IL-34).
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DOI：
10.1016/j.cyto.2012.11.014
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发表时间：
2013-02
期刊：
影响因子：
3.8
通讯作者：
Hume, David A.
中科院分区：
文献类型：
--
作者：
Gow, Deborah J.;Garceau, Valerie;Pridans, Clare;Gow, Adam G.;Simpson, Kerry E.;Gunn-Moore, Danielle;Hume, David A.
► Full-length feline CSF-1R has been cloned and expressed in a stable cell line. ► The biological activity of human, mouse and porcine CSF-1 has been evaluated. ► Human and mouse IL-34 are also biologically active on the feline CSF-1R. ► The potential therapeutic applications of CSF-1 is discussed. Colony stimulating factor (CSF-1) and its receptor, CSF-1R, have been previously well studied in humans and rodents to dissect the role they play in development of cells of the mononuclear phagocyte system. A second ligand for the CSF-1R, IL-34 has been described in several species. In this study, we have cloned and expressed the feline CSF-1R and examined the responsiveness to CSF-1 and IL-34 from a range of species. The results indicate that pig and human CSF-1 and human IL-34 are equally effective in cats, where both mouse CSF-1 and IL-34 are significantly less active. Recombinant human CSF-1 can be used to generate populations of feline bone marrow and monocyte derived macrophages that can be used to further dissect macrophage-specific gene expression in this species, and to compare it to data derived from mouse, human and pig. These results set the scene for therapeutic use of CSF-1 and IL-34 in cats.
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影响因子：
1.8
作者：
Bienzle, D;Reggeti, F;Chow, C
通讯作者：
Chow, C
影响因子：
19.6
作者：
Awad, Alaa S.;Rouse, Michael;Huang, Liping;Vergis, Amy L.;Reutershan, Joerg;Cathro, Helen P.;Linden, Joel;Okusa, Mark D.
通讯作者：
Okusa, Mark D.
影响因子：
1.8
作者：
Arai, M;Darmen, J;Yamamoto, JK
通讯作者：
Yamamoto, JK
影响因子：
7.3
作者：
Guillot, P. V.;Cook, H. T.;Bou-Gharios, G.
通讯作者：
Bou-Gharios, G.
影响因子：
6.5
作者：
Abrams, K;Yunusov, MY;Nash, RA
通讯作者：
Nash, RA