Long-Term Effects of SARS-CoV-2 in the Brain: Clinical Consequences and Molecular Mechanisms.
Long-Term Effects of SARS-CoV-2 in the Brain: Clinical Consequences and Molecular Mechanisms.
复制标题
DOI：
10.3390/jcm12093190
复制
发表时间：
2023-04-28
影响因子：
3.9
通讯作者：
Granholm, Ann-Charlotte
中科院分区：
文献类型：
--
作者：
Granholm, Ann-Charlotte
关键词：
许多研究已经证明了COVID-19的显著和持久的神经系统表现。有人认为，五分之四的COVID-19患者会出现一种或多种神经系统症状，这些症状可能会在感染结束后持续数月。神经系统症状在60岁以下的人群中最常见，而脑病在60岁以上的人群中更常见。这些神经系统症状的生物学机制需要研究，可能包括病毒对大脑和脊髓的直接和间接影响。阿尔茨海默病（AD）和相关痴呆症患者以及唐氏综合征（DS）患者特别容易感染COVID-19，但其生物学原因尚不清楚。调查COVID-19的神经系统后果是一项紧迫的新兴医疗需求，因为全球近7亿人至少感染过一次COVID-19。很可能会给医疗保健和经济带来新的负担，以应对严重的SARS-CoV-2感染和长期COVID的长期神经系统后果，即使是在年轻一代中。有趣的是，急性感染后的神经系统症状与轻度创伤性脑损伤（mTBI）或脑震荡后观察到的症状惊人相似，包括头晕，平衡问题，嗅觉丧失和头痛。将讨论两者所涉及的生物学途径的可能趋同。目前的审查集中在最常见的神经系统症状，以及可能的分子机制。
Numerous investigations have demonstrated significant and long-lasting neurological manifestations of COVID-19. It has been suggested that as many as four out of five patients who sustained COVID-19 will show one or several neurological symptoms that can last months after the infection has run its course. Neurological symptoms are most common in people who are less than 60 years of age, while encephalopathy is more common in those over 60. Biological mechanisms for these neurological symptoms need to be investigated and may include both direct and indirect effects of the virus on the brain and spinal cord. Individuals with Alzheimer’s disease (AD) and related dementia, as well as persons with Down syndrome (DS), are especially vulnerable to COVID-19, but the biological reasons for this are not clear. Investigating the neurological consequences of COVID-19 is an urgent emerging medical need, since close to 700 million people worldwide have now had COVID-19 at least once. It is likely that there will be a new burden on healthcare and the economy dealing with the long-term neurological consequences of severe SARS-CoV-2 infections and long COVID, even in younger generations. Interestingly, neurological symptoms after an acute infection are strikingly similar to the symptoms observed after a mild traumatic brain injury (mTBI) or concussion, including dizziness, balance issues, anosmia, and headaches. The possible convergence of biological pathways involved in both will be discussed. The current review is focused on the most commonly described neurological symptoms, as well as the possible molecular mechanisms involved.
登录
查看更多内容
DOI：
10.1183/16000617.0098-2016
发表时间：
2017-01
期刊：
European respiratory review : an official journal of the European Respiratory Society
影响因子：
--
作者：
通讯作者：
--
DOI：
10.5662/wjm.v12.i4.200
发表时间：
2022-07-20
期刊：
World journal of methodology
影响因子：
--
作者：
Al-Beltagi, Mohammed;Saeed, Nermin Kamal;Bediwy, Adel Salah
通讯作者：
Bediwy, Adel Salah
影响因子：
7.3
作者：
Bodnar CN;Watson JB;Higgins EK;Quan N;Bachstetter AD
通讯作者：
Bachstetter AD
影响因子：
5.6
作者：
Bocci M;Oudenaarden C;Sàenz-Sardà X;Simrén J;Edén A;Sjölund J;Möller C;Gisslén M;Zetterberg H;Englund E;Pietras K
通讯作者：
Pietras K
影响因子：
5.8
作者：
Andolfo I;Russo R;Lasorsa VA;Cantalupo S;Rosato BE;Bonfiglio F;Frisso G;Abete P;Cassese GM;Servillo G;Esposito G;Gentile I;Piscopo C;Villani R;Fiorentino G;Cerino P;Buonerba C;Pierri B;Zollo M;Iolascon A;Capasso M
通讯作者：
Capasso M