Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection.
Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection.
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DOI：
10.3748/wjg.v24.i2.248
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发表时间：
2018-01-14
影响因子：
4.3
通讯作者：
Velavan TP
中科院分区：
文献类型：
--
作者：
Sy BT;Hoan NX;Tong HV;Meyer CG;Toan NL;Song LH;Bock CT;Velavan TP
研究IFR 5基因座3' UTR区域的IRF 5多态性对临床分类的越南患者感染B型肝炎病毒（HBV）的易感性和肝病进展的可能影响。在临床分类的HBV患者[慢性乙型肝炎B（CH B）]中对4种IFR 5 SNP（rs 13242262 A/T、rs77416878 C/T、rs 10488630 A/G和rs 2280714 T/C）进行基因分型。n = 99;肝硬化（LC），n = 131;肝细胞癌（HCC），n = 149]和242名健康对照。比较患者和对照组，没有观察到四种IFR 5变体的显著相关性。然而，等位基因rs 13242262 T和rs 10488630 G导致肝硬化风险增加（LC vs CHB：OR = 1.5，95%CI：1.1-2.3，校正P = 0.04; LC vs CHB：OR = 1.7，95%CI：1.1-2.6，校正P = 0.019）。与慢性乙型肝炎患者相比，在LC中观察到由4个SNP构建的单倍型IRF 5 *TCGT（OR = 2.1，95%CI：1.2-3.3，校正P = 0.008）。单倍型IRF 5 *TCAT在CHB患者中的发生率高于其他HBV患者组（LC vs CHB：OR = 0.4，95%CI：0.2-0.8，校正P = 0.03; HCC vs CHB：OR = 0.3，95%CI：0.15-0.7，校正P = 0.003）。IRF 5 *TCAT单倍型也与ALT、AST和胆红素水平升高相关。我们的研究表明，IFR 5变异体可能有助于作为一个主机因素，在确定慢性HBV感染的发病机制。
To investigate possible effects of IRF5 polymorphisms in the 3’ UTR region of the IFR5 locus on susceptibility to hepatitis B virus (HBV) infection and progression of liver diseases among clinically classified Vietnamese patients. Four IFR5 SNPs (rs13242262A/T, rs77416878C/T, rs10488630A/G, and rs2280714T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B (CHB). n = 99; liver cirrhosis (LC), n = 131; hepatocellular carcinoma (HCC), n = 149] and in 242 healthy controls by direct sequencing and TaqMan real-time PCR assays. Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262T and rs10488630G contributed to an increased risk of liver cirrhosis (LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients (OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups (LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections.
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影响因子：
5
作者：
Fang, C-M;Roy, S.;Nielsen, E.;Paul, M.;Maul, R.;Paun, A.;Koentgen, F.;Raval, F. M.;Szomolanyi-Tsuda, E.;Pitha, P. M.
通讯作者：
Pitha, P. M.
DOI：
10.1007/s11901-010-0055-1
发表时间：
2010-11
期刊：
Current hepatitis reports
影响因子：
--
作者：
Rijckborst, Vincent;Janssen, Harry L A
通讯作者：
Janssen, Harry L A
影响因子：
4.8
作者：
Chen W;Royer WE Jr
通讯作者：
Royer WE Jr
影响因子：
30.8
作者：
Hu, Zhibin;Liu, Yao;Shen, Hongbing
通讯作者：
Shen, Hongbing
影响因子：
--
作者：
Hoan NX;Van Tong H;Giang DP;Toan NL;Meyer CG;Bock CT;Kremsner PG;Song LH;Velavan TP
通讯作者：
Velavan TP