T cell immunity to SARS-CoV-2 following natural infection and vaccination.

T cell immunity to SARS-CoV-2 following natural infection and vaccination.
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DOI:
10.1016/j.bbrc.2020.10.060
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发表时间:
2021-01-29
影响因子:
3.1
通讯作者:
Ruckwardt TJ
Ruckwardt TJ
中科院分区:
生物学4区
文献类型:
--
作者:
DiPiazza AT;Graham BS;Ruckwardt TJ

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SARS-CoV-2于2019年底在中国武汉首次出现在人群中,并在几个月内传播到全球,导致冠状病毒病19 (COVID-19)大流行和严重的经济后果。SARS-CoV-2通过呼吸道颗粒在人与人之间传播,感染表现出一系列临床表现,从无症状到呼吸衰竭伴多器官功能障碍,严重者死亡。人类致病性冠状病毒和呼吸道病毒疾病的以往经验表明,细胞免疫在限制疾病严重程度方面发挥着重要作用。在这里,我们回顾了细胞介导的呼吸道病毒免疫的一些关键机制,并总结了我们目前对自然感染和疫苗接种后sars - cov -2特异性T细胞的功能和作用的理解。
SARS-CoV-2 first emerged in the human population in late 2019 in Wuhan, China, and in a matter of months, spread across the globe resulting in the Coronavirus Disease 19 (COVID-19) pandemic and substantial economic fallout. SARS-CoV-2 is transmitted between humans via respiratory particles, with infection presenting a spectrum of clinical manifestations ranging from asymptomatic to respiratory failure with multiorgan dysfunction and death in severe cases. Prior experiences with human pathogenic coronaviruses and respiratory virus diseases in general have revealed an important role for cellular immunity in limiting disease severity. Here, we review some of the key mechanisms underlying cell-mediated immunity to respiratory viruses and summarize our current understanding of the functional capacity and role of SARS-CoV-2-specific T cells following natural infection and vaccination.
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发表时间: 2020-07-29
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