Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain: nationwide seroepidemiological study.
Infection fatality risk for SARS-CoV-2 in community dwelling population of Spain: nationwide seroepidemiological study.
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DOI：
10.1136/bmj.m4509
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发表时间：
2020-11-27
期刊：
影响因子：
--
通讯作者：
ENE-COVID Study Group
中科院分区：
文献类型：
--
作者：
Pastor-Barriuso R;Pérez-Gómez B;Hernán MA;Pérez-Olmeda M;Yotti R;Oteo-Iglesias J;Sanmartín JL;León-Gómez I;Fernández-García A;Fernández-Navarro P;Cruz I;Martín M;Delgado-Sanz C;Fernández de Larrea N;León Paniagua J;Muñoz-Montalvo JF;Blanco F;Larrauri A;Pollán M;ENE-COVID Study Group
以确诊的2019冠状病毒病（covid-19）死亡人数和各种原因造成的超额死亡人数为基础，估计严重急性呼吸综合征冠状病毒2 （SARS-CoV-2）的感染死亡风险。全国血清流行病学研究。西班牙出现第一波covid-19大流行。所有年龄的社区居民。主要结局指标是西班牙社区居民中SARS-CoV-2感染的总体、年龄和性别特异性死亡风险（covid-19死亡人数和超额死亡人数除以SARS-CoV-2估计感染人数）。截至2020年7月15日，实验室确诊的covid-19死亡人数来自国家流行病学监测网（RENAVE），剩余全因死亡人数来自死亡率监测系统（MoMo）。西班牙的SARS-CoV-2感染是根据2020年4月27日至6月22日参加ENE-COVID全国血清流行病学调查的61 098名参与者中IgG抗体的化学发光微粒免疫测定法估计的血清阳性率得出的。确诊covid-19死亡的总感染死亡风险为0.8%(230万感染者中有19 228人，95%可信区间为0.8%至0.9%)，超额死亡的总感染死亡风险为1.1%（230万感染者中有24 778人，1.0%至1.2%）。男性感染死亡风险为1.1%（95%可信区间1.0%至1.2%）至1.4%(1.3%至1.5%)，女性为0.6%（0.5%至0.6%）至0.8%（0.7%至0.8%）。50岁以后感染死亡风险急剧增加，80岁以上男性的死亡率从11.6%（8.1%至16.5%）到16.4%（11.4%至23.2%）不等，80岁以上女性的死亡率从4.6%（3.4%至6.3%）到6.5%（4.7%至8.8%）不等。50岁以后，男性感染SARS-CoV-2死亡风险的增加似乎比女性更明显。根据这项研究的结果，covid-19的死亡率高于其他常见呼吸道疾病（如季节性流感）的死亡率。
To estimate the infection fatality risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on deaths with confirmed coronavirus disease 2019 (covid-19) and excess deaths from all causes. Nationwide seroepidemiological study. First wave of covid-19 pandemic in Spain. Community dwelling individuals of all ages. The main outcome measure was overall, and age and sex specific, infection fatality risk for SARS-CoV-2 (the number of covid-19 deaths and excess deaths divided by the estimated number of SARS-CoV-2 infections) in the community dwelling Spanish population. Deaths with laboratory confirmed covid-19 were obtained from the National Epidemiological Surveillance Network (RENAVE) and excess all cause deaths from the Monitoring Mortality System (MoMo), up to 15 July 2020. SARS-CoV-2 infections in Spain were derived from the estimated seroprevalence by a chemiluminescent microparticle immunoassay for IgG antibodies in 61 098 participants in the ENE-COVID nationwide seroepidemiological survey between 27 April and 22 June 2020. The overall infection fatality risk was 0.8% (19 228 of 2.3 million infected individuals, 95% confidence interval 0.8% to 0.9%) for confirmed covid-19 deaths and 1.1% (24 778 of 2.3 million infected individuals, 1.0% to 1.2%) for excess deaths. The infection fatality risk was 1.1% (95% confidence interval 1.0% to 1.2%) to 1.4% (1.3% to 1.5%) in men and 0.6% (0.5% to 0.6%) to 0.8% (0.7% to 0.8%) in women. The infection fatality risk increased sharply after age 50, ranging from 11.6% (8.1% to 16.5%) to 16.4% (11.4% to 23.2%) in men aged 80 or more and from 4.6% (3.4% to 6.3%) to 6.5% (4.7% to 8.8%) in women aged 80 or more. The increase in SARS-CoV-2 infection fatality risk after age 50 appeared to be more noticeable in men than in women. Based on the results of this study, fatality from covid-19 was greater than that reported for other common respiratory diseases, such as seasonal influenza.
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影响因子：
19
作者：
Cottrell, Simon;Moore, Catherine;Shankar, Ananda Giri
通讯作者：
Shankar, Ananda Giri
DOI：
10.1016/j.ijid.2020.09.1464
发表时间：
2020-12
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Meyerowitz-Katz G;Merone L
通讯作者：
Merone L
影响因子：
158.5
作者：
McMichael, Temet M.;Currie, Dustin W.;Duchin, Jeffrey S.
通讯作者：
Duchin, Jeffrey S.
影响因子：
168.9
作者：
Pollan, Marina;Perez-Gomez, Beatriz;Yotti, Raquel
通讯作者：
Yotti, Raquel
DOI：
10.1016/s0140-6736(16)30164-7
发表时间：
2016-08-13
期刊：
Lancet (London, England)
影响因子：
--
作者：
Metcalf CJ;Farrar J;Cutts FT;Basta NE;Graham AL;Lessler J;Ferguson NM;Burke DS;Grenfell BT
通讯作者：
Grenfell BT