Antibiotic-associated pseudomembranous colitis: an epidemiologic investigation of a cluster of cases.
Antibiotic-associated pseudomembranous colitis: an epidemiologic investigation of a cluster of cases.
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抗生素相关性伪膜性结肠炎：一组病例的流行病学调查。
DOI：
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发表时间：
1982
影响因子：
6.4
通讯作者：
J. Hughes
中科院分区：
文献类型：
--
作者：
P. Pierce;R. Wilson;Joseph Silva;V. Garagusi;G. Rifkin;R. Fekety;O. Nunez;V. Dowell;J. Hughes
1979 年 3 月 17 日至 5 月 9 日，华盛顿特区的一家医院发现了 10 例抗生素相关性结肠炎 (AAC) 病例。没有发现病例的地理聚集性，也没有发现与抗生素使用增加之间的关联。接触氨基糖苷类、头孢菌素类和克林霉素与发病前 7 天内的灌肠史与 AAC 相关（P=0.045）。当胃肠道手术（定义为（1）每周 3 次或以上灌肠，（2）插入鼻胃管两天或以上，或（3）胃肠道手术）在发病后 7 天内进行时，这种关联得到加强（P=0.007）。艰难梭菌并未从医院环境、护理人员或患者家属中分离出来。从作为对照的 14 名患者中的 5 名 (36%) 的粪便标本中分离出艰难梭菌。
Ten cases of antibiotic-associated colitis (AAC) were identified at a hospital in Washington, D.C., from March 17 to May 9, 1979. No geographic clustering of cases was found, nor was an association with increased use of antibiotics demonstrated. Exposure to aminoglycosides, cephalosporins, and clindamycin was associated with AAC, as was a history of enemas in the seven days before the onset of illness (P=0.045). This association was strengthened when gastrointestinal procedures-defined as (1) three or more enemas per week, (2) the insertion of a nasogastric tube for two or more days, or (3) gastrointestinal surgery-were performed within seven days of the onset of illness (P=0.007). Clostridium difficile was not isolated from the hospital environments, nursing personnel, or family members of the patients. C. difficile was isolated from stool specimens of five (36%) of 14 patients who served as controls.
DOI：
10.1093/infdis/143.1.51
发表时间：
1981
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Toshniwal,R;SilvaJr,J;Fekety,R;Kim,KH
通讯作者：
Kim,KH