A novel risk classification score for malignant ureteral obstruction: a multicenter prospective validation study.
A novel risk classification score for malignant ureteral obstruction: a multicenter prospective validation study.
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DOI：
10.1038/s41598-021-84054-7
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发表时间：
2021-02-24
影响因子：
4.6
通讯作者：
Mizokami A
中科院分区：
文献类型：
--
作者：
Izumi K;Shima T;Shigehara K;Sawada K;Naito R;Kato Y;Ofude M;Kano H;Iwamoto H;Yaegashi H;Nakashima K;Iijima M;Kawaguchi S;Nohara T;Kadono Y;Mizokami A
恶性输尿管梗阻（MUO）的出现已被报道为预后不良的标志，然而，MUO患者的生存时间分布相当广泛，并且没有建立风险分类评分。评估我们以前开发的总生存率的新风险分类评分在大型队列中是否有效。进行了研究者发起的前瞻性多中心诊断/预后研究。根据首次访视时使用4个预后因素（PLaCT：原发部位、偏侧性、血清肌酐水平和原发部位治疗）计算的评分，将MUO患者分为3个风险组，并进行前瞻性随访。比较各组的总生存率和输尿管支架无失效生存率。总共入组了21个不同主要部位的300例患者。良好、中等和不良风险组的患者数量分别为105、106和89。好、中、差风险组患者的中位生存时间分别为406、221和77天（P < 0.0001）。在217例输尿管支架植入患者中，好、中、差风险组的输尿管支架无失效生存时间中位数分别为385、183和57天（P < 0.0001）。局限性包括种族限制和研究入组持续时间延长。新的PLaCT风险分类评分可以将MUO患者分为三个风险组，具有不同的生存时间和输尿管支架通畅率。该评分将有助于为所有从事癌症治疗的医生建立预后和治疗策略。
Emergence of malignant ureteral obstruction (MUO) has been reported as a sign of poor prognosis; however, the distribution of survival time in patients with MUO is considerably wide, and no risk classification score has been constructed. To evaluate whether a novel risk classification score for overall survival that we previously developed, is effective in a large cohort. Investigator-initiated, prospective, multicenter diagnostic/prognostic study was conducted. Patients with MUO were divided into three risk groups based on the score calculated using four prognostic factors (PLaCT: Primary site, Laterality, serum Creatinine level, and Treatment for primary site) at the first visit, and prospective follow-up was performed. Overall survival and ureteral stent failure-free survival of each risk group were compared. In total, 300 patients with 21 different primary sites were enrolled. The numbers of patients in good, intermediate, and poor risk groups were 105, 106, and 89, respectively. Median survival times of patients in good, intermediate, and poor risk groups were 406, 221, and 77 days, respectively (P < 0.0001). In 217 patients with ureteral stenting, median ureteral stent failure-free survival times of good, intermediate, and poor risk groups were 385, 183, and 57 days, respectively (P < 0.0001). Limitations include the limited ethnicity and the extended duration of study enrollment. The novel PLaCT risk classification score could divide MUO patients into three risk groups with distinct survival times and ureteral stent patencies. This score will aid in establishing prognosis and treatment strategy for all physicians engaged in cancer treatment.
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DOI：
10.1016/1.jvir.2017.02.031
发表时间：
2017-07-01
影响因子：
2.9
作者：
McDevitt, Joseph L.;Acosta-Torres, Stefany;Pillai, Anil K.
通讯作者：
Pillai, Anil K.
DOI：
10.5527/wjn.v5.i2.172
发表时间：
2016-03-06
期刊：
World journal of nephrology
影响因子：
--
作者：
Hsu, Linda;Li, Hanhan;Sammon, Jesse
通讯作者：
Sammon, Jesse
影响因子：
2.6
作者：
Asakawa, Jumpei;Iguchi, Taro;Nakatani, Tatsuya
通讯作者：
Nakatani, Tatsuya
影响因子：
4.5
作者：
Cordeiro, Maurcio D.;Coelho, Rafael F.;Srougi, Miguel
通讯作者：
Srougi, Miguel
影响因子：
3.7
作者：
Donat, SM;Russo, P
通讯作者：
Russo, P