Cancer risks for relatives of patients with serrated polyposis.
Cancer risks for relatives of patients with serrated polyposis.
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DOI：
10.1038/ajg.2012.52
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发表时间：
2012-05
影响因子：
9.8
通讯作者：
Young, Joanne P.
中科院分区：
文献类型：
--
作者：
Win, Aung Ko;Walters, Rhiannon J.;Buchanan, Daniel D.;Jenkins, Mark A.;Sweet, Kevin;Frankel, Wendy L.;de la Chapelle, Albert;McKeone, Diane M.;Walsh, Michael D.;Clendenning, Mark;Pearson, Sally-Ann;Pavluk, Erika;Nagler, Belinda;Hopper, John L.;Gattas, Michael R.;Goldblatt, Jack;George, Jill;Suthers, Graeme K.;Phillips, Kerry D.;Woodall, Sonja;Arnold, Julie;Tucker, Kathy;Field, Michael;Greening, Sian;Gallinger, Steve;Aronson, Melyssa;Perrier, Renee;Woods, Michael O.;Green, Jane S.;Walker, Neal;Rosty, Christophe;Parry, Susan;Young, Joanne P.
锯齿状息肉病（增生性息肉病）的特征是在结直肠中有多个具有锯齿状结构的息肉。虽然已知锯齿状息肉病患者患结直肠癌（CRC）以及可能患结直肠外癌症的风险增加，但他们亲属的癌症风险尚未得到广泛探究。本研究的目的是评估锯齿状息肉病患者亲属患CRC和结直肠外癌症的风险。
对来自澳大利亚、新西兰、加拿大和美国遗传诊所的100例锯齿状息肉病先证者的1639名一级和二级亲属组成的队列进行了回顾性分析，这些亲属的招募不考虑息肉或癌症家族史，以评估亲属与普通人群相比的国家、年龄和性别特异性标准化发病比（SIR）。
在一级和二级亲属中总共观察到102例CRC（SIR为2.25，95%置信区间，CI为1.75 - 2.93；P < 0.001），其中一级亲属中有54例（SIR为5.16，95% CI为3.70 - 7.30；P < 0.001），二级亲属中有48例（SIR为1.38，95% CI为1.01 - 1.91；P = 0.04）。在一级亲属中观察到6例胰腺癌（SIR为3.64，95% CI为1.70 - 9.21；P = 0.003）。没有统计学证据表明胃癌、脑癌、乳腺癌或前列腺癌的风险增加。
我们发现锯齿状息肉病患者的亲属患结直肠癌和胰腺癌的风险显著增加，这进一步增加了锯齿状息肉病具有遗传成分的证据。
Serrated polyposis (hyperplastic polyposis) is characterized by multiple polyps with serrated architecture in the colorectum. While patients with serrated polyposis are known to be at increased risk of colorectal cancer (CRC) and possibly extracolonic cancers, cancer risk for their relatives has not been widely explored. The aim of this study was to estimate the risks of CRC and extracolonic cancers for relatives of patients with serrated polyposis. A cohort of the 1,639 first- and second-degree relatives of 100 index patients with serrated polyposis recruited regardless of a family history of polyps or cancer from genetic clinics in Australia, New Zealand, Canada and the USA, were retrospectively analysed to estimate the country-, age- and sex-specific standardized incidence ratios (SIRs) for relatives compared with the general population. A total of 102 CRCs were observed in first- and second-relatives (SIR 2.25, 95% confidence interval, CI 1.75-2.93; P<0.001), with 54 in first-degree relatives (SIR 5.16, 95% CI 3.70-7.30; P<0.001) and 48 in second-degree relatives (SIR 1.38, 95% CI 1.01-1.91; P=0.04). Six pancreatic cancers were observed in first-degree relatives (SIR 3.64, 95% CI 1.70-9.21; P=0.003). There was no statistical evidence of increased risk for cancer of the stomach, brain, breast or prostate. Our finding that relatives of serrated polyposis patients are at significantly increased risk of colorectal and pancreatic cancer, adds to the accumulating evidence that serrated polyposis has an inherited component.
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影响因子：
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