The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice.
The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice.
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DOI：
10.1016/j.neuropharm.2015.01.027
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发表时间：
2015-06
影响因子：
4.7
通讯作者：
Cardona-Gómez GP
中科院分区：
文献类型：
--
作者：
Sabogal-Guáqueta AM;Muñoz-Manco JI;Ramírez-Pineda JR;Lamprea-Rodriguez M;Osorio E;Cardona-Gómez GP
Alzheimer’s disease (AD) is the most common senile dementia in the world. Although important progress has been made in understanding the pathogenesis of AD, current therapeutic approaches provide only modest symptomatic relief. In this study, we evaluated the neuroprotective effect of quercetin (25 mg/kg) administration via i.p. injection every 48 hours for 3 months on aged (21–24 months old) triple transgenic AD model (3xTg-AD) mice. Our data show that quercetin decreases extracellular β-amyloidosis, tauopathy, astrogliosis and microgliosis in the hippocampus and the amygdala. These results were supported by a significant reduction in the paired helical filament (PHF), β-amyloid (βA) 1–40 and βA 1–42 levels and a decrease in BACE1-mediated cleavage of APP (into CTFβ). Additionally, quercetin induced improved performance on learning and spatial memory tasks and greater risk assessment behavior based on the elevated plus maze test. Together, these findings suggest that quercetin reverses histological hallmarks of AD and protects cognitive and emotional function in aged 3xTg-AD mice.
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DOI：
10.1054/plef.2002.0387
发表时间：
2002-05-01
影响因子：
3
作者：
Banerjee, T;Van der Vliet, A;Ziboh, VA
通讯作者：
Ziboh, VA
影响因子：
4.8
作者：
Ho, Lap;Ferruzzi, Mario G.;Pasinetti, Giulio Maria
通讯作者：
Pasinetti, Giulio Maria
影响因子：
8.2
作者：
Gimenez-Llort, L.;Blazquez, G.;Fernandez-Teruel, A.
通讯作者：
Fernandez-Teruel, A.
影响因子：
4.3
作者：
Jia, Ning;Han, Kun;Cao, Yun-Peng
通讯作者：
Cao, Yun-Peng
影响因子：
3.4
作者：
Cao, Xiaoguang;Liu, Melissa;Tuo, Jingsheng;Shen, Defen;Chan, Chi-Chao
通讯作者：
Chan, Chi-Chao