Sexual interactions influence the molecular oscillations in DN1 pacemaker neurons in Drosophila melanogaster.
Sexual interactions influence the molecular oscillations in DN1 pacemaker neurons in Drosophila melanogaster.
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DOI：
10.1371/journal.pone.0084495
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Yoshii T
中科院分区：
文献类型：
--
作者：
Hanafusa S;Kawaguchi T;Umezaki Y;Tomioka K;Yoshii T
昼夜节律可以与环境时间线索同步，例如光、温度、湿度和食物供应。先前的研究表明，这些节奏也可以通过社交互动来控制。在这里，我们使用果蝇作为模型来研究社会性相互作用对行为和起搏神经元的生物钟的影响。如果将两只异性果蝇配对并饲养在一个狭小的空间中，则两只果蝇的日常活动模式明显不同于单个雄性和雌性果蝇的活动总和。与单蝇相比，成对果蝇在夜间和早晨更加活跃，雌性活动期活动较多，雄性活动期活动较少。这些行为表型与求偶行为有关，但与生物钟无关。然而，在时钟速度不同的雌雄果蝇中（野生型果蝇和每 S 果蝇），雄性大脑中 DN1 起搏器神经元的时钟蛋白循环受到其伴侣的轻微影响。这些结果表明，男女伴侣之间的性互动可以作为 DN1 起搏神经元的微弱时间，但其效果不足以改变行为活动的节律。
Circadian rhythms can synchronize to environmental time cues, such as light, temperature, humidity, and food availability. Previous studies have suggested that these rhythms can also be entrained by social interactions. Here, we used Drosophila melanogaster as a model to study the influence of socio-sexual interactions on the circadian clock in behavior and pacemaker neurons. If two flies of opposite sex were paired and kept in a small space, the daily activity patterns of the two flies were clearly different from the sum of the activity of single male and female flies. Compared with single flies, paired flies were more active in the night and morning, were more active during females’ active phase, and were less active during males’ active phase. These behavioral phenotypes are related to courtship behavior, but not to the circadian clock. Nevertheless, in male-female pairs of flies with clocks at different speeds (wild-type and per S flies), clock protein cycling in the DN1 pacemaker neurons in the male brain were slightly influenced by their partners. These results suggest that sexual interactions between male-female couples can serve as a weak zeitgeber for the DN1 pacemaker neurons, but the effect is not sufficient to alter rhythms of behavioral activity.
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