Mother-to-child transmission of HIV and its predictors among HIV-exposed infants at a PMTCT clinic in northwest Ethiopia.
Mother-to-child transmission of HIV and its predictors among HIV-exposed infants at a PMTCT clinic in northwest Ethiopia.
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DOI：
10.1186/1471-2458-13-398
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发表时间：
2013-04-27
影响因子：
4.5
通讯作者：
Zeleke BM
中科院分区：
文献类型：
--
作者：
Koye DN;Zeleke BM
HIV 母婴传播 (MTCT) 占儿童获得性免疫缺陷综合症 (AIDS) 病例的 90% 以上。预防母婴传播（PMTCT）计划具有双重好处，即预防艾滋病毒母婴传播以及让受感染的孕妇及其家人接受抗逆转录病毒治疗（ART）。这项研究评估了转诊医院预防母婴传播诊所随访中暴露于艾滋病毒的婴儿中艾滋病毒传播的风险和预测因素。贡德尔大学转诊医院预防母婴传播诊所进行了基于机构的回顾性随访研究。 2005 年 9 月至 2011 年 7 月期间登记的所有符合条件的 HIV 暴露婴儿记录均包括在内。助产士护士使用结构化数据提取格式收集数据。然后将数据输入EPI INFO 3.5.1版统计软件并通过SPSS 20.0版进行分析。进行双变量和多变量分析以确定关联性。分析中总共纳入了 509 份婴儿记录。入组随访时婴儿的中位年龄为 6 周（四分位数范围 [IQR] = 2 周）。共有 51 名（10%，95% CI：7.8% - 13%）婴儿感染 HIV。延迟入组到暴露婴儿随访诊所（调整后比值比[AOR] = 2.89，95% CI：1.35，6.21），农村居住（AOR = 5.05，95% CI：2.34，10.9），家庭分娩（AOR = 2.82，95% CI：1.2， 6.64）、缺乏母亲预防母婴传播干预（AOR = 5.02，95% CI：2.43，10.4）和混合婴儿喂养方式（AOR = 4.18，95% CI：1.59，10.99）在本研究中与 HIV 母婴传播显着且独立相关。在贡德尔大学转诊医院预防母婴传播诊所随访的暴露婴儿中，艾滋病毒母婴传播的风险很高。这项研究的结果将为政策制定者提供宝贵的信息，以加强对预防母婴传播扩大计划中农村环境的承诺和支持。
Mother-to-child transmission of HIV (MTCT) accounts for more than 90% of pediatric Acquired Immunodeficiency Syndrome (AIDS) cases. Prevention of mother to child transmission (PMTCT) programs are provided for dual benefits i.e. prevention of HIV transmission from mother to child and enrolment of infected pregnant women and their families into antiretroviral treatment (ART). This study assessed risk and predictors of HIV transmission among HIV-exposed infants on follow up at a PMTCT clinic in a referral hospital. Institution based retrospective follow up study was carried at Gondar University referral hospital PMTCT clinic. All eligible records of HIV-exposed infants enrolled between September 2005 and July 2011 were included. A midwife nurse collected data using a structured data extraction format. Data were then entered in to EPI INFO Version 3.5.1 statistical software and analyzed by SPSS version 20.0. Both bivariate and multivariate analyses were carried out to identify associations. A total of 509 infant records were included in the analysis. The median age of infants at enrolment to follow up was 6 weeks (inter quartile range [IQR] = 2 weeks). A total of 51(10%, 95% CI: 7.8% - 13%) infants were infected with HIV. Late enrolment to the exposed infant follow up clinic (Adjusted Odds Ratio [AOR] = 2.89, 95% CI: 1.35, 6.21), rural residence (AOR = 5.05, 95% CI: 2.34, 10.9), home delivery (AOR = 2.82, 95% CI: 1.2, 6.64), absence of maternal PMTCT interventions (AOR = 5.02, 95% CI: 2.43, 10.4) and mixed infant feeding practices (AOR = 4.18, 95% CI: 1.59, 10.99) were significantly and independently associated with maternal to child transmission of HIV in this study. There is a high risk of MTCT of HIV among exposed infants on follow up at the PMTCT clinic of the University of Gondar referral hospital. The findings of this study will provide valuable information for policy makers to enhance commitment and support for rural settings in the PMTCT scaling-up program.
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影响因子：
2.8
作者：
Mirkuzie AH;Hinderaker SG;Mørkve O
通讯作者：
Mørkve O
影响因子：
11.8
作者：
Giaquinto, C;Ruga, E;Horban, A
通讯作者：
Horban, A
DOI：
10.1177/1545109710363920
发表时间：
2010-03-01
期刊：
Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002)
影响因子：
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作者：
Viani, Rolando M;Ruiz-Calderon, Jorge;Spector, Stephen A
通讯作者：
Spector, Stephen A
DOI：
10.1097/qai.0b013e3181cf9979
发表时间：
2010-05-01
影响因子：
3.6
作者：
Hoffman, Risa M.;Black, Vivian;Chersich, Matthew
通讯作者：
Chersich, Matthew
影响因子：
3.8
作者：
Ciaranello, Andrea L.;Seage, George R., III;Walensky, Rochelle P.
通讯作者：
Walensky, Rochelle P.