Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy.
Materials for multifunctional balloon catheters with capabilities in cardiac electrophysiological mapping and ablation therapy.
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作者：
开发用于微创手术的先进手术工具对改善人类健康至关重要。一个关键的材料难题是在半导体和传感器技术类别之间实现生物相容性接口，这些技术在此背景下可能最为有用，同时要考虑到人体柔软的曲线表面。本文描述了一种基于生物相容性材料和设备的解决方案，该方案可直接与传统球囊导管的薄弹性膜集成，以提供适合临床使用的多模态功能。我们展示了用于测量温度、流量、触觉、光学和电生理数据的传感器，以及用于控制局部组织消融的射频（RF）电极。这些组件以阵列布局连接在一起，旨在使其操作与部署和反复充气/放气相关的大应变变形解耦。在活体动物模型和体外试验中使用这种“仪器化”球囊导管装置说明了它们在心脏消融治疗中的操作。这些概念有可能应用于未来的手术系统，不仅是基于导管的系统，还包括其他平台，如手术手套。
Development of advanced surgical tools for minimally invasive procedures represents an activity of central importance to improvements in human health. A key materials challenge is in the realization of bio-compatible interfaces between the classes of semiconductor and sensor technologies that might be most useful in this context and the soft, curvilinear surfaces of the body. This paper describes a solution based on biocompatible materials and devices that integrate directly with the thin elastic membranes of otherwise conventional balloon catheters, to provide multimodal functionality suitable for clinical use. We present sensors for measuring temperature, flow, tactile, optical and electrophysiological data, together with radio frequency (RF) electrodes for controlled, local ablation of tissue. These components connect together in arrayed layouts designed to decouple their operation from large strain deformations associated with deployment and repeated inflation/deflation. Use of such ‘instrumented’ balloon catheter devices in live animal models and in vitro tests illustrates their operation in cardiac ablation therapy. These concepts have the potential for application in surgical systems of the future, not only those based on catheters but also on other platforms, such as surgical gloves.
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影响因子：
2.8
作者：
Rich, S;Dodin, E;McLaughlin, VV
通讯作者：
McLaughlin, VV
影响因子：
2.4
作者：
Mathur, AB;Collinsworth, AM;Truskey, GA
通讯作者：
Truskey, GA
影响因子：
41.2
作者：
Kim, Rak-Hwan;Kim, Dae-Hyeong;Rogers, John A.
通讯作者：
Rogers, John A.
DOI：
10.1152/ajpheart.1998.275.5.h1886
发表时间：
1998-11-01
影响因子：
4.8
作者：
Macchi, E;Cavalieri, M;Taccardi, B
通讯作者：
Taccardi, B
影响因子：
39.3
作者：
Chun, Kyoung-Ryul Julian;Schmidt, Boris;Kuck, Karl Heinz
通讯作者：
Kuck, Karl Heinz