Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa.
Rapid epidemic expansion of the SARS-CoV-2 Omicron variant in southern Africa.
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DOI：
10.1038/s41586-022-04411-y
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发表时间：
2022-03
期刊：
影响因子：
64.8
通讯作者：
de Oliveira T
中科院分区：
文献类型：
--
作者：
Viana R;Moyo S;Amoako DG;Tegally H;Scheepers C;Althaus CL;Anyaneji UJ;Bester PA;Boni MF;Chand M;Choga WT;Colquhoun R;Davids M;Deforche K;Doolabh D;du Plessis L;Engelbrecht S;Everatt J;Giandhari J;Giovanetti M;Hardie D;Hill V;Hsiao NY;Iranzadeh A;Ismail A;Joseph C;Joseph R;Koopile L;Kosakovsky Pond SL;Kraemer MUG;Kuate-Lere L;Laguda-Akingba O;Lesetedi-Mafoko O;Lessells RJ;Lockman S;Lucaci AG;Maharaj A;Mahlangu B;Maponga T;Mahlakwane K;Makatini Z;Marais G;Maruapula D;Masupu K;Matshaba M;Mayaphi S;Mbhele N;Mbulawa MB;Mendes A;Mlisana K;Mnguni A;Mohale T;Moir M;Moruisi K;Mosepele M;Motsatsi G;Motswaledi MS;Mphoyakgosi T;Msomi N;Mwangi PN;Naidoo Y;Ntuli N;Nyaga M;Olubayo L;Pillay S;Radibe B;Ramphal Y;Ramphal U;San JE;Scott L;Shapiro R;Singh L;Smith-Lawrence P;Stevens W;Strydom A;Subramoney K;Tebeila N;Tshiabuila D;Tsui J;van Wyk S;Weaver S;Wibmer CK;Wilkinson E;Wolter N;Zarebski AE;Zuze B;Goedhals D;Preiser W;Treurnicht F;Venter M;Williamson C;Pybus OG;Bhiman J;Glass A;Martin DP;Rambaut A;Gaseitsiwe S;von Gottberg A;de Oliveira T
南部非洲的SARS-CoV-2疫情有三个不同的特点。第一波与SARS-CoV-2谱系的混合有关，而第二波和第三波分别由Beta（B.1.351）和Delta（B.1.617.2）变体驱动。2021年11月，南非和博茨瓦纳的基因组监测团队在南非豪登省检测到一种新的SARS-CoV-2变异株，该变异株与感染病例迅速死灰复燃有关。在第一个基因组被上传后的三天内，它被世界卫生组织指定为一个令人关注的变体（Omicron，B.1.1.529），并在三周内在87个国家被确定。Omicron变体在刺突糖蛋白中携带超过30个突变是例外，这些突变预计会影响抗体中和和刺突功能。在这里，我们描述的基因组概况和早期的传播动力学的Omicron，突出了快速传播的地区具有高水平的人口免疫力。SARS-CoV-2 Omicron株的基因组图谱和早期传播动力学。
The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves. The first was associated with a mix of SARS-CoV-2 lineages, while the second and third waves were driven by the Beta (B.1.351) and Delta (B.1.617.2) variants, respectively. In November 2021, genomic surveillance teams in South Africa and Botswana detected a new SARS-CoV-2 variant associated with a rapid resurgence of infections in Gauteng province, South Africa. Within three days of the first genome being uploaded, it was designated a variant of concern (Omicron, B.1.1.529) by the World Health Organization and, within three weeks, had been identified in 87 countries. The Omicron variant is exceptional for carrying over 30 mutations in the spike glycoprotein, which are predicted to influence antibody neutralization and spike function. Here we describe the genomic profile and early transmission dynamics of Omicron, highlighting the rapid spread in regions with high levels of population immunity. The genomic profile and early transmission dynamics of the Omicron strain of SARS-CoV-2.
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DOI：
10.1126/science.abg3055
发表时间：
2021-04-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Davies NG;Abbott S;Barnard RC;Jarvis CI;Kucharski AJ;Munday JD;Pearson CAB;Russell TW;Tully DC;Washburne AD;Wenseleers T;Gimma A;Waites W;Wong KLM;van Zandvoort K;Silverman JD;CMMID COVID-19 Working Group;COVID-19 Genomics UK (COG-UK) Consortium;Diaz-Ordaz K;Keogh R;Eggo RM;Funk S;Jit M;Atkins KE;Edmunds WJ
通讯作者：
Edmunds WJ
影响因子：
4.3
作者：
Bragg LM;Stone G;Butler MK;Hugenholtz P;Tyson GW
通讯作者：
Tyson GW
影响因子：
3.4
作者：
Benvenuto, Domenico;Giovanetti, Marta;Ciccozzi, Massimo
通讯作者：
Ciccozzi, Massimo
影响因子：
5.8
作者：
Cleemput, Sara;Dumon, Wim;de Oliveira, Tulio
通讯作者：
de Oliveira, Tulio
影响因子：
10.7
作者：
Drummond, Alexei J.;Suchard, Marc A.;Rambaut, Andrew
通讯作者：
Rambaut, Andrew